Publications by authors named "Richard A Leather"

Objectives: The purpose of this study was to evaluate the efficacy, health care utilization, and safety of a same-day discharge protocol.

Background: Catheter ablation of atrial fibrillation (AF) is the most common ablation performed. Increasing volumes of AF ablation are placing demands on hospital resources.

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Article Synopsis
  • Pathogenic gain-of-function variants in the CACNA1C gene are responsible for type-8 long QT syndrome (LQT8), and this study aims to describe associated electrocardiographic features and understand the genetic mechanisms involved.
  • Researchers identified rare variants and assessed their pathogenicity, discovering nine notable variants affecting 23 patients from 19 families, with many clustering in a specific region of the Cav1.2 protein related to SH3 domain binding.
  • Key findings include a common late-peaking T wave morphology on EKG and evidence of QT prolongation after exercise, with a concerning history of sudden death linked to variants in the II-III loop region.
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Canadian electrophysiology (EP) fellowship programs have evolved in an ad hoc fashion over 30 years. This evolution has occurred in many fields in medicine and is natural when innovators and pioneers attract research fellows who help change the status quo from predominantly research to a predominantly clinical application and focus. Fellows not only push their supervisors and their centres into new areas of inquiry but also function at the most advanced level to encourage and teach junior trainees and to provide examples of excellence to residents, medical students, and other health professionals.

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We present the first reported case of an entire family, 3 sisters, all presenting with symptomatic atrioventricular reciprocating tachycardia during a 15-year period, all were found at electrophysiological study to have identically located left lateral accessory pathway, all successfully treated with radiofrequency ablation. This rare familial clustering suggests a genetic contribution to pathway formation.

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Hospitalization due to heart failure (HF) exacerbation represents a major burden in health care and portends a poor long-term prognosis for patients. As a result, there is considerable interest to develop novel tools and strategies to better detect onset of volume overload, as HF hospitalizations may be reduced if appropriate interventions can be promptly delivered. One such innovation is the use of device-based diagnostic parameters in HF patients with implantable cardioverter defibrillators (ICD) and/or cardiac resynchronization therapy (CRT) devices.

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We report a case of complete heart block associated with tricuspid endocarditis due to extended-spectrum β-lactamase-producing Escherichia coli (ESBL E. coli) following a transrectal prostate biopsy. This is the first report of complete heart block associated with tricuspid native valve endocarditis.

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Introduction. For pulmonary vein isolation in patients with atrial fibrillation (AF), some centers use the double transseptal puncture technique for catheter access in order to facilitate catheter manipulation within the left atrium. However, no safety data has so far been published using this approach.

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Introduction: Percutaneous catheter ablation for atrial fibrillation (AF) is a procedure performed typically in an inpatient setting. The feasibility and safety of catheter ablation in patients with paroxysmal and persistent AF were evaluated on an outpatient basis.

Methods: 230 AF ablation procedures were performed in 206 patients (74% male; mean age 56+/-9 years).

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Background: Although the incidence of atrial fibrillation (AF) progressively increases with age, the vast majority of AF ablation is done in middle-aged patients. We evaluated the feasibility and safety of catheter ablation in patients older than 65 years of age with paroxysmal and persistent AF.

Methods: Out of a total of 230 consecutive AF ablation procedures, 45 patients were older than 65 years of age and underwent 53 procedures.

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Aims: Small elevations in troponin T levels have been shown with limited radiofrequency (RF) ablation procedures for supraventricular tachycardia, usually to levels below the threshold for ischaemia or infarction. Left atrial catheter ablation for atrial fibrillation (AF) requires far more RF energy, therefore could be expected to have greater elevation in troponin T. We determined troponin T levels before and after ablation in these patients to evaluate the amount of rise with this ablation.

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