Publications by authors named "Richard A Kwiatek"
Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI.
J Cereb Blood Flow Metab
August 2024
Article Synopsis
- People with Myalgic Encephalitis/Chronic Fatigue Syndrome (ME/CFS) often have brain-related problems, but scientists still don't fully understand why.
- A study was done using MRI scans to see how blood flow in the brain changes when both ME/CFS patients and healthy people perform thinking tasks.
- The results showed that ME/CFS patients had more brain activity in one area compared to healthy participants, which might help explain why they feel more tired and have trouble with tasks.
Introduction: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is a debilitating illness affecting up to 24 million people worldwide but concerningly there is no known mechanism for ME/CFS and no objective test for diagnosis. A series of our neuroimaging findings in ME/CFS, including functional MRI (fMRI) signal characteristics and structural changes in brain regions particularly sensitive to hypoxia, has informed the hypothesis that abnormal neurovascular coupling (NVC) may be the neurobiological origin of ME/CFS. NVC is a critical process for normal brain function, in which glutamate from an active neuron stimulates Ca influx in adjacent neurons and astrocytes.
View Article and Find Full Text PDFBackground: Since the 1990s, neuroimaging has been utilised to study Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating illness with unknown aetiology. While brain abnormalities in ME/CFS have been identified, relatively little is known regarding which specific abnormalities are consistently observed across research groups and to what extent the observed abnormalities are reproducible.
Method: To identify consistent and inconsistent neuroimaging observations in ME/CFS, this retrospective and systematic review searched for studies in which neuroimaging was used to investigate brain abnormalities in ME/CFS in Ovid MEDLINE, PubMed (NCBI), and Scopus from January 1988 to July 2018.