Estimated Cost of Transcarotid Arterial Revascularization Compared With Carotid Endarterectomy and Transfemoral Carotid Stenting.

Objectives Transcarotid arterial revascularization (TCAR) is associated with a lower risk of stroke or death than transfemoral carotid artery stenting (TF-CAS). TCAR infers a lower risk of cranial nerve injury and a similar risk of myocardial infarction (MI) than carotid endarterectomy (CEA). There have been no comparative studies on the cost of TCAR, TF-CAS, and CEA, which may have important implications for institutional support for the new modality to address carotid artery stenosis.

Periprosthetic joint infection.

Periprosthetic joint infections are a devastating complication after arthroplasty and are associated with substantial patient morbidity. More than 25% of revisions are attributed to these infections, which are expected to increase. The increased prevalence of obesity, diabetes, and other comorbidities are some of the reasons for this increase.

Temporary polysaccharide dermal fillers: a model for persistence based on physical properties.

Background: The physical and chemical properties that control the clinical persistence of temporary dermal fillers are not well understood. Discovering the relationship between the clinical performance and physical properties of temporary fillers may stimulate the design of future, high-performance fillers.

Objective: Described here is the rheology of polysaccharide dermal fillers composed of cross-linked hyaluronic acid (XLHA) or un-cross-linked sodium carboxymethylcellulose (CMC) and polyethylene oxide (PEO).

Crosslinked hyaluronic acid dermal fillers: a comparison of rheological properties.

Temporary dermal fillers composed of crosslinked hyaluronic acid (XLHA) are space filling gels that are readily available in the United States and Europe. Several families of dermal fillers based on XLHA are now available and here we compare the physical and rheological properties of these fillers to the clinical effectiveness. The XLHA fillers are prepared with different crosslinkers, using HA isolated from different sources, have different particle sizes, and differ substantially in rheological properties.

Novel synthetic dermal fillers based on sodium carboxymethylcellulose: comparison with crosslinked hyaluronic acid-based dermal fillers.

Background: The persistence of dermal fillers containing crosslinked hyaluronic acid (XLHA) correlates linearly to the concentration of polymer in solution. For dermal fillers composed of XLHA, a polymer concentration above approximately 25 mg/mL is not practical because it cannot be easily injected through a small-bore needle.

Objective: Formulating dermal fillers from mixtures of carboxymethylcellulose (CMC) and polyethylene oxide (PEO) has several advantages over XLHA.

Rheological and cohesive properties of hyaluronic acid.

Hyaluronic acid (HA) is a naturally occurring polysaccharide with unique biomedical applications. We have studied the cohesive and rheological properties of HA of three molecular weights (0.35 x 10(6) -1.

Reduction of epidural fibrosis in lumbar surgery with Oxiplex adhesion barriers of carboxymethylcellulose and polyethylene oxide.

Background Context: Postsurgical epidural adhesions and fibrosis after surgery for lumbar disc herniation are a consequence of normal wound healing. The presence of fibrosis renders reoperations risky, and in some patients fibrosis may lead to nerve root tethering.

Purpose: One approach to minimizing the risk of developing epidural adhesions is to provide a barrier between the dural membrane and the healing connective tissues.

Adhesion barriers of carboxymethylcellulose and polyethylene oxide composite gels.

Composite gels and films of CMC and PEO have been used to separate healing tissues and have been demonstrated to reduce postsurgical adhesions in animal models of adhesion formation. Gels of CMC/PEO were studied here to elucidate the mechanism by which the combination of PEO with CMC is effective in reducing adhesions between tissues. CMC and PEO were demonstrated to undergo micro phase separation to form a two-phase system.