Publications by authors named "Richard A Ashmun"
Although BCL-xL is critical to the survival of mature erythrocytes, it is still unclear whether other antiapoptotic molecules mediate survival during earlier stages of erythropoiesis. Here, we demonstrate that erythroid-specific Mcl1 deletion results in embryonic lethality beyond embryonic day 13.5 as a result of severe anemia caused by a lack of mature red blood cells (RBCs).
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- * Researchers conducted single-cell transcriptomics on 25 medulloblastomas to explore the heterogeneity within and between tumor types, noting specific characteristics for each subgroup.
- * The study found that different tumor groups have unique populations of undifferentiated and differentiated cells, with specific cell types correlating to patient age; this sheds light on the cellular development that drives the distinct behaviors of each medulloblastoma subtype.
Efficacy and toxicity of a virus-directed enzyme prodrug therapy purging method: preclinical assessment and application to bone marrow samples from neuroblastoma patients.
Cancer Res
September 2002
Autologous stem cell transplantation is used to rescue cancer patients from myelosuppression caused by high-dose chemotherapy. However, autologous grafts often contain tumor cells that can contribute directly to relapse. Current purging methods are useful when fewer than 1% tumor cells contaminate the bone marrow, and patients with tumor burdens of >1% are considered ineligible for chemotherapy that necessitates stem cell rescue.
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