Publications by authors named "Rich Gang Li"
Article Synopsis
- - The study focuses on understanding how adult heart cells (cardiomyocytes) remain in a state of cell cycle arrest and how the YAP5SA protein can help them re-enter the cell cycle, offering insights into their growth and division.
- - Researchers used various methods, including clonal analyses and single-cell RNA sequencing, to examine the characteristics and behaviors of cardiomyocytes influenced by YAP5SA.
- - Findings indicate that while YAP5SA cardiomyocytes can efficiently divide after exiting the cycle, there are barriers, like the checkpoint activity from P21, that hinder their progression through the cycle, suggesting new ways to understand and potentially manipulate cardiac cell division.
Background: The Hippo pathway effector YAP (Yes-associated protein) plays an essential role in cardiomyocyte proliferation and heart regeneration. In response to physiological changes, YAP moves in and out of the nucleus. The pathophysiological mechanisms regulating YAP subcellular localization after myocardial infarction remain poorly defined.
View Article and Find Full Text PDFAfter myocardial infarction (MI), mammalian hearts do not regenerate, and the microenvironment is disrupted. Hippo signaling loss of function with activation of transcriptional co-factor YAP induces heart renewal and rebuilds the post-MI microenvironment. In this study, we investigated adult renewal-competent mouse hearts expressing an active version of YAP, called YAP5SA, in cardiomyocytes (CMs).
View Article and Find Full Text PDFHomology Directed Repair (HDR)-based genome editing is an approach that could permanently correct a broad range of genetic diseases. However, its utility is limited by inefficient and imprecise DNA repair mechanisms in terminally differentiated tissues. Here, we tested "Repair Drive", a novel method for improving targeted gene insertion in the liver by selectively expanding correctly repaired hepatocytes .
View Article and Find Full Text PDFCardiomyocytes are differentiated heart muscle cells with minimal self-renewal ability. Thus, loss of cardiomyocytes from cardiovascular disease and injury cannot be effectively replenished. Recent studies in animal models have indicated that induction of endogenous cardiomyocyte proliferation is essential for cardiac renewal and that inhibiting the Hippo signaling pathway can stimulate cardiomyocyte proliferation and heart regeneration.
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