Histamine H3-receptor blockade in the rat nucleus basalis magnocellularis improves place recognition memory.

Rationale: Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory

Objectives: The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of the rat.

Methods: The effects of thioperamide, a histamine H3-receptor antagonist, were studied on the memory performance of rats in a two-trial, delayed, place-recognition task. The drug was injected into the NBM area 2 min prior to the first trial (1.