Publications by authors named "Riccardo Trozzo"
B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), remain incurable, with MM particularly prone to relapse. Our study introduces a novel mouse model with active RANK signaling and the TCL1 oncogene, displaying both CLL and MM phenotypes. In younger mice, TCL1 and RANK expression expands CLL-like B1-lymphocytes, while MM originates from B2-cells, becoming predominant in later stages and leading to severe disease progression and mortality.
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- Long noncoding RNAs (lncRNAs) are prevalent in the genome, but their functions are not well understood, partly due to their overlap with other genetic sequences.
- The researchers developed a new genome-scale screening method using Cas13d/CasRx to explore lncRNAs more effectively, overcoming limitations of previous methods.
- They created a targeted library called Albarossa, focusing on 24,171 lncRNA genes, which improves the ability to discover important lncRNAs across various cancers while addressing challenges like transcriptome size and tissue specificity.
Gastric neuroendocrine carcinomas (G-NEC) are aggressive malignancies with poorly understood biology and a lack of disease models. Here, we use genome sequencing to characterize the genomic landscapes of human G-NEC and its histologic variants. We identify global and subtype-specific alterations and expose hitherto unappreciated gains of MYC family members in a large part of cases.
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