Publications by authors named "Riccardo Padolecchia"
Background And Purpose: We sought to investigate whether there are gender differences in clinical outcome after stroke due to large vessel occlusion (LVO) after mechanical thrombectomy (EVT) in a large population of real-world patients.
Methods: From the Italian Registry of Endovascular Thrombectomy, we extracted clinical and outcome data of patients treated for stroke due to large vessel occlusion. We compared clinical and safety outcomes in men and women who underwent EVT alone or in combination with intravenous thrombolysis (IVT) in the total population and in a Propensity Score matched set.
Background And Purpose: To evaluate outcome and safety of endovascular treatment beyond 6 hours of onset of ischemic stroke due to large vessel occlusion in the anterior circulation, in routine clinical practice.
Methods: From the Italian Registry of Endovascular Thrombectomy, we extracted clinical and outcome data of patients treated for stroke of known onset beyond 6 hours. Additional inclusion criteria were prestroke modified Rankin Scale score ≤2 and ASPECTS score ≥6.
Article Synopsis
- There is currently no reliable system to predict the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke, prompting the development of a nomogram to address this issue.
- The study analyzed data from 3714 patients treated for large vessel occlusion and created the IER-SICH nomogram based on various factors, including age and procedure time, to assess hemorrhage risk.
- The IER-SICH nomogram demonstrated good predictive ability, with area under the curve values of 0.778 in the training set and 0.709 in the test set, making it the first validated model for early identification of high-risk patients post-thrombectomy.
Article Synopsis
- The study aimed to create and validate a new nomogram, called IER-START, to predict unfavorable outcomes in stroke patients with large vessel occlusion who received intervention within 6 hours.
- This nomogram was based on key factors like the NIH Stroke Scale score, age, previous disability levels, and treatment methods, utilizing data from the Italian Endovascular Registry.
- The IER-START model demonstrated strong predictive performance, with an AUC-ROC of 0.838 in training and 0.820 in testing, making it a reliable tool for assessing patient outcomes after thrombectomy.
Spinal Dural Arteriovenous Fistulas: Clinical Results and Quality of Life Assessment with Surgical Treatment as a Crucial Therapy. The Joint Experience of Two Centers.
World Neurosurg
February 2019
Objective: Dorsal intradural arteriovenous fistulas (AVFs) consist of a direct connection between a radicular feeding artery and the coronal venous plexus; this direct connection leads to arterialization of the venous plexus, venous congestion, and myelopathy. Controversy still exists regarding the best treatment modality of spinal dural AVFs. Surgical disconnection of spinal dural AVFs is a straightforward procedure with a high success rate and virtually no risk of recurrence or incomplete treatment.
View Article and Find Full Text PDFBackground: Diffuse leptomeningeal glioneuronal tumor (DLGNT) was recently added to the World Health Organization classification of central nervous system tumors. DLGNT is a rare entity that occurs more commonly in pediatric patients, but occasional cases have been reported in adults. This tumor has been recognized as a distinct pathologic entity; however, its biologic behavior remains unclear.
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- Endovascular treatment (ET) is recognized as a safe method for treating acute strokes, but there is ongoing debate about its effectiveness compared to intravenous thrombolysis.
- The Italian Registry of Endovascular Treatment in Acute Stroke is a national, observational study initiated in 2010 that collects data from various centers to analyze patient outcomes and treatment safety.
- Over 960 patients were included in the registry from 2008-2012, revealing important insights into treatment methods, safety measures, and demographic characteristics, which can inform future studies on stroke treatments.
Introduction: We report the experiences of 25 Italian centers, analyzing intra- and periprocedural complications of endovascular treatment of intracranial aneurysms using Silk (Balt Extrusion, Montmorency, France) and pipeline embolization devices (EV3 Inc, Irvine California).
Methods: Two hundred seventy-three patients with 295 cerebral aneurysms, enrolled in 25 centers in Italy and treated with the new flow-diverter devices, were evaluated; 142 patients were treated with Silk and 130 with pipeline (in one case, both devices were used). In 14 (5.
Objective: The aim of this preliminary study was to investigate the physiologic substrate of executive function in anorexia nervosa (AN) by assessing the relation between brain perfusion and Stroop interference task (SIT).
Method: The classical SIT test and brain single-photon emission tomography (SPET) were evaluated in 16 AN females (mean age = 23.69 +/- 8.
Many tumors, including meningiomas, express somatostatin receptors, suggesting the application of somatostatin analogues for therapy and diagnosis. Sixty percent of meningiomas are associated with perilesional edema, whose development seems to be related to the vascular endothelial growth factor, although it requires an efficient pial blood supply. However, in several neoplastic models, other mediators seem to cooperate with vascular endothelial growth factor in regulating angiogenesis.
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