PRODE recovers essential and context-essential genes through neighborhood-informed scores.

Gene context-essentiality assessment supports precision oncology opportunities. The variability of gene effects inference from loss-of-function screenings across models and technologies limits identifying robust hits. We propose a computational framework named PRODE that integrates gene effects with protein-protein interactions to generate neighborhood-informed essential (NIE) and neighborhood-informed context essential (NICE) scores.

Psychological-Emotional Aspect and Lifestyle in Professional Males Rugby Athletes.

Background: Recent research emphasizes the importance of integrating psychological-emotional factors with nutrition and body composition in athletes. This study investigates the correlations between these aspects in 36 professional rugby players, aiming to identify relationships that could optimize sports performance and overall well-being.

Methods: The study sample included 36 male athletes (mean age: 24.

Altering operational conditions during protein fermentation to volatile fatty acids modifies the associated bacterial community.

In recent years, the production of volatile fatty acids (VFA) through mixed culture fermentation (MCF) has been gaining attention. Most authors have focused on the fermentation of carbohydrates, while other possible substrates, such as proteins, have not been considered. Moreover, there is little information about how operational parameters affect the microbial communities involved in these processes, even though they are strongly related to reactor performance and VFA selectivity.

Protein composition determines the preferential consumption of amino acids during anaerobic mixed-culture fermentation.

The valorisation of protein-rich residual streams by anaerobic mixed-culture fermentation (MCF) has been barely studied in contrast to carbohydrate-rich wastes. The aim of this work was, therefore, to investigate how protein composition, i.e.

A metabolic model for targeted volatile fatty acids production by cofermentation of carbohydrates and proteins.

Anaerobic mixed-culture fermentations are interesting processes to valorise organic wastes by converting them to volatile fatty acids. One of the main issues is that certain operational conditions (e.g.

Ultrasound-guided compression repair of femoral pseudoaneurysms complicating cardiac catheterization.

Background: Femoral pseudoaneurysms complicate cardiac catheterizations in up to 3.2% of cases. Ultrasound-guided compression repair (UGCR) is a known valid alternative therapy to surgical and percutaneous repair.