Immune reactions associated with silicone-based ventriculo-peritoneal shunt malfunctions in children.

The implantation of ventriculo-peritoneal (VP) shunting systems is the most commonly performed neurological procedure in children with hydrocephalus. Although the overall complication risk is low, the cumulative risk of shunt failure is high and unfortunately results in a high prevalence of revision surgeries. In this study, we explored the concept that some pediatric patients may develop an immune response to either the proteins attached to the silicone implant surface or to the biomaterial itself, and that this reaction may contribute to VP shunt failure in some individuals.

Impact of an asthma program on the quality of life of children in an urban setting.

A comprehensive asthma program involving a pharmacist and physician evaluated quality of life (QOL) for children with asthma and the relationship between changes in QOL and traditional outcomes. The program consisted of aggressive medical management and a comprehensive education program. Children were from an inner-city population who had been referred to a specialist.

Upper airway disorders and asthma: a syndrome of airway inflammation.

Objective: This article presents recent evidence of an upper and lower airway link. After reading this article, readers should have an understanding of the evidence for the pathologic relationship between asthma and upper airway disorders such as rhinosinusitis and allergic rhinitis.

Data Sources: Epidemiologic, pathophysiologic, and treatment outcomes studies were used.