Publications by authors named "Ricardo Xisto"
Int J Biochem Cell Biol
October 2019
Article Synopsis
- Melanoma is a highly aggressive skin cancer linked to high mortality rates, partly due to its ability to spread (metastasize) and elevated reactive oxygen species (ROS) levels, like superoxide anion.
- Nitric oxide synthase (NOS) can become dysfunctional (uncoupled), producing more ROS when there's a lack of its cofactor tetrahydrobiopterin (BH4), which is crucial for its proper function.
- Treating melanoma cells with BH4 restores NOS function, increasing nitric oxide production, reducing harmful ROS, and ultimately leading to decreased cell growth, reduced ability to form tumors, and increased sensitivity to programmed cell death (apoptosis).
