Spontaneous Vitiligo in a Captive Rhesus Monkey ().

Vitiligo affects a significant portion of human and animal populations. The disease causes irregular and multifocal progressive loss of fur, skin, and mucous membrane pigmentation due to the loss or absence of melanocytes. While etiopathogenesis is not completely understood, autoimmunity, environmental, and genetic factors are implicated We present a case report on a 16-y-old female rhesus macaque ( ) with depigmented areas that are progressively increasing on the skin and coat and are distributed on the head and back.

Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors.

The botulinum neurotoxin, the caustic agent that causes botulism, is the most lethal toxin known to man. The neurotoxin composed of a heavy chain (HC) and a light chain (LC) enters neurons and cleaves SNARE proteins, leading to flaccid paralysis, which, in severe occurrences, can result in death. A therapeutic target for botulinum neurotoxin (BoNT) intoxication is the LC, a zinc metalloprotease that directly cleaves SNARE proteins.

Autocatalytic Cycles in a Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction.

This work describes the autocatalytic copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction between tripropargylamine and 2-azidoethanol in the presence of Cu(II) salts. The product of this reaction, tris-(hydroxyethyltriazolylmethyl)amine (N(CN)), accelerates the cycloaddition reaction (and thus its own production) by two mechanisms: (i) by coordinating Cu(II) and promoting its reduction to Cu(I) and (ii) by enhancing the catalytic reactivity of Cu(I) in the cycloaddition step. Because of the cooperation of these two processes, a rate enhancement of >400× is observed over the course of the reaction.

The platysma window: an anatomically safe, efficient, and easily reproducible approach to neck contour in the face lift.

Background: The cornerstone of the face lift is neck contour. The pursuit of reliable and reproducible results has led plastic surgeons to investigate a multitude of different approaches. Unfortunately, addressing neck contour can lead to complications such as injury to the great auricular nerve.