Insulin sensitivity and pancreatic β-cell function in patients with primary aldosteronism.

Background: Primary aldosteronism (PA) is associated with an increased risk for dysglycemia. However, the effects of hyperaldosteronism on insulin sensitivity and β-cell function are unclear.

Methods: Using a cross-sectional study design, we assessed insulin sensitivity and pancreatic β-cell function from an oral glucose tolerance test (OGTT) in patients from two cohorts: subjects with PA (n = 21) and essential hypertension control (EHC) subjects (n = 22).

PERCEPTION OF GRADUATING ENDOCRINOLOGY, DIABETES, AND METABOLISM FELLOWS ON THE BENEFITS OF WEARING A CONTINUOUS GLUCOSE MONITOR AND/OR INSULIN PUMP FOR THEIR EDUCATION.

To our knowledge, no prior research has explored the prevalence of wearing continuous glucose monitors (CGMs) and/or insulin pumps among in-training fellows and their perception of doing so as part of their education. Our objectives therefore were to estimate the frequency with which wearing a CGM and/or insulin pump is used as a learning opportunity and explore the main motivators and perception on its value. A multiple-choice survey that addressed each fellow's level of training, type of fellowship training program, and use of CGM and/or insulin pump was sent to all Accreditation Council for Graduate Medical Education endocrinology, diabetes, and metabolism program coordinators or program directors.

Screening for GPR101 defects in pediatric pituitary corticotropinomas.

Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been identified in pediatric CD, but the genetic defects in a significant percentage of cases are still unknown. We investigated the orphan G protein-coupled receptor GPR101, a gene known to be involved in somatotropinomas, for its possible involvement in corticotropinomas.