Publications by authors named "Ricardo Pinheiro"
COMT ValMet polymorphism protects the impact of a mother's history of childhood trauma on emotional and behavioural problems in preschool children.
Eur J Neurosci
December 2024
Article Synopsis
- Childhood trauma negatively affects mental health and can be passed down to future generations, impacting the emotional and behavioral issues of children.
- The study analyzed 310 preschool-aged children to see how maternal childhood trauma interacted with genetic factors, specifically the COMT ValMet variant, and assessed behavioral problems using established questionnaires.
- Results showed that while maternal trauma generally increases behavioral issues in children, those with the Val/Met genotype are less prone to certain problems compared to those with other genetic variants, highlighting the importance of both trauma and genetics in child development.
Article Synopsis
- About 6-13% of women globally experience antenatal depression (AD), which can harm both mother and baby; the study explored the link between vitamin D deficiency and AD in pregnant women in Pelotas, Brazil.
- A cross-sectional study analyzed blood samples from 180 pregnant women (50 with depression) to measure levels of 25-hydroxyvitamin D, finding a significant association between vitamin D deficiency and AD.
- The findings suggest that maintaining adequate vitamin D levels during pregnancy may help reduce the risk of AD and support maternal mental health, potentially benefiting child development as well.
Maternal hsa-miR-423-5p associated with the cognitive development of babies in pregnant women without mental disorders.
Front Hum Neurosci
February 2024
Article Synopsis
- MicroRNAs (miRNAs), such as hsa-miR-423-5p, play a significant role in regulating gene expression and are important for various biological processes, especially during pregnancy when maternal health impacts infant development.
- A longitudinal study conducted in southern Brazil examined the relationship between maternal levels of hsa-miR-423-5p in early pregnancy and cognitive development in infants at 90 days old, using blood samples and cognitive assessments.
- Results showed that higher maternal levels of miR-423-5p correlate with better cognitive abilities in infants, suggesting this miRNA could serve as a prenatal biomarker for predicting and potentially improving child neurocognitive development through early interventions.
Objective: To assess risk factors associated with motor development delay at three months of age.
Methods: Cross-sectional study with mothers and their three-month-old babies in Southern Brazil. The Bayley-III Scale of Infant and Toddler Development (BSID-III) and the Alberta Infant Motor Scale (AIMS) were used to assess motor development.
This study evaluates the association of birth conditions with attention deficit/hyperactivity disorders (ADHD) in adults using data from two birth cohorts in the city of Pelotas Rio Grande do Sul State, Brazil. In 1982 and 1993 all births in the city were identified and have been prospectively monitored. In the follow-ups at 30 and 22 years of the 1982 (n = 3,574) and 1993 (n = 3,780) cohorts, respectively, participants were examined, and trained psychologists applied the Mini-International Neuropsychiatric Interview (M.
View Article and Find Full Text PDFBackground: Exposure and introduction to digital media, especially in children, are a current cause for concern. The negative links associated with early screen exposure are extensive.
Aims: To evaluate the association between the time of exposure to a screen in children at 18 months of age and cognitive development in a population-based sample in Southern Brazil.
Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the neuropsychomotor development of 90 days old babies: "Pregnancy care, healthy baby" study.
J Psychiatr Res
February 2023
Article Synopsis
- This study investigates the role of maternal microRNAs, specifically miR-let-7d-3p and miR-451a, during the second trimester of pregnancy and their impact on infant neuropsychomotor development at 90 days old.
- It uses a case-control design comparing pregnant women with Major Depressive Episode (MDE) and those without MDE, assessing child development through established scales and analyzing microRNA levels from maternal serum.
- The findings reveal a negative correlation between miR-451a and cognitive development, while miR-let-7d-3p showed positive associations with both cognitive and motor development in infants, highlighting the importance of these microRNAs during pregnancy.
Article Synopsis
- Research explored how temperament traits impact bipolar disorder (BD) and their connection to genetic variations in the CACNA1C gene, particularly in relation to biological sex.
- A study of 878 Caucasian individuals aged 18-35 in Brazil found that certain temperament traits mediated the relationship between specific genetic polymorphisms and BD, particularly in women.
- The results suggested that temperament traits function as endophenotypes for BD in females, but no effects were observed in cisgender men, highlighting a sex-specific interaction in the genetic-temperament-BD link.
Article Synopsis
- * It focused on two specific genetic variants: OXTR rs2254298, which was identified as a risk factor for both ADHD and anxiety, and CD38 rs6449182, associated with ADHD risk.
- * The findings offer insights into the genetic factors influencing developmental and behavioral disorders, highlighting the need for further research to better understand their underlying neurobiology in children.
Background: Maternal anxiety disorders can cause adverse consequences in child's health, cognitive development, and behavior.
Aim: To investigate the association of maternal anxiety disorders with the occurrence of dental fear in children aged 24-36 months.
Design: This cross-sectional study is part of a cohort of adolescent mothers and their children (n = 527) in the city of Pelotas, RS, Brazil.
Background: The literature reports that teenage pregnancy is considered a risk factor for anxiety disorders (ADs). However, research on this topic is limited. This study aimed to investigate if pregnant adolescents presented a greater likelihood of having ADs by comparing two samples of pregnant women in a southern city of Brazil.
View Article and Find Full Text PDFRobbery is one of the most common urban crimes, but little is known about its relationship with mental disorders in young adults. This study aimed to assess the relationship between robbery victimization and Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD) and comorbidity between MDD and GAD at 30 years of age. A birth cohort study has followed all children born in the city of Pelotas, southern Brazil, since 1982.
View Article and Find Full Text PDFThe COVID-19 pandemic has changed individuals and families, causing adverse psychological effects, especially in young adults, women, and parents. This study aimed to verify the prevalence of current major depressive episode (CMDE) in mothers of preschoolers (up to five years old) and its associated stressors during the COVID-19 pandemic in a municipality in the Southern Brazil. This is a cross-sectional, population-based study with mothers.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between the COMT Val Met polymorphism and depression among young adults in Pelotas, Brazil, without finding a direct link to depression itself.
- It reveals that the Met-allele of the Val Met polymorphism significantly affects the impact of childhood trauma on depression risk, specifically in men who experienced trauma.
- The findings suggest that childhood trauma combined with genetic factors could influence gene regulation related to depression susceptibility, highlighting a complex interplay between genetics and early life experiences in mental health outcomes.
Article Synopsis
- Research indicates a potential link between thyroid antibodies and depression during pregnancy and after childbirth, prompting a systematic review to examine postpartum depression (PPD) prevalence in women with thyroid issues.
- The review analyzed 15 studies from various databases, primarily using a mix of study designs (case-control, cross-sectional, and prospective cohort), focusing on outcomes within the first year postpartum.
- Prevalence rates of PPD among pregnant women with thyroid disorders ranged from 8.3% to 36.0%, but it remains unclear if thyroid function directly contributes to the onset of PPD, despite some suggestions that positive anti-TPO antibodies might indicate increased vulnerability.
Java vulnerabilities correspond to 91% of all exploits observed on the worldwide web. The present work aims to create antivirus software with machine learning and artificial intelligence and master in Java malware detection. Within the proposed methodology, the suspected JAR sample is executed to intentionally infect the Windows OS monitored in a controlled environment.
View Article and Find Full Text PDFAntenatal depression: Efficacy of a pre-post therapy study and repercussions in motor development of children during the first 18 months postpartum. Study: "Pregnancy care, healthy baby".
J Psychiatr Res
April 2022
Article Synopsis
- The study assessed the effectiveness of brief cognitive behavioral therapy for treating antenatal depression and its impact on infant motor development at 3 and 18 months.
- Data was collected from 336 non-intervened women and 108 women receiving therapy, showing an 80% effectiveness in reducing major depressive episodes in the treatment group.
- Infants whose mothers received therapy scored higher in motor development tests compared to the control group, indicating positive effects on child development linked to maternal mental health interventions.
Article Synopsis
- Postpartum depression (PPD) significantly impacts many women and is often the first sign of future mood disorders; this study evaluated the effectiveness of preventive cognitive behavioral therapy (CBT) for PPD.
- Pregnant women at risk for depression were split into a CBT therapy group and a control group, with results showing a higher prevalence of PPD in the risk group but no significant difference between groups; the OQ-45 scores decreased, indicating improvement during therapy.
- The study faced limitations, including a high refusal rate for treatment and lack of comparison with another therapy type, but concluded that brief CBT is effective in preventing PPD.
Article Synopsis
- The study investigates the relationship between maternal-fetal attachment (MFA) and the perceived parental bonds among pregnant women in Pelotas, Brazil.
- Findings indicate that women who experienced higher paternal overprotection reported stronger MFA, while those in their first trimester, without a partner, or lacking support from the baby's father showed lower MFA scores.
- The research highlights the importance of the father's influence on women's emotional connections to their fetus, emphasizing that support and presence during pregnancy can enhance feelings of care and affection.
Background: Family members tend to modify their routine by assisting or participating in the patient's rituals. These behaviors have been identified as family accommodation (FA).
Aims: The aim of this study was to describe the relationship between family accommodation of relatives of Obsessive-Compulsive Disorder (OCD) patients and their perceptions about the obsessions and compulsions of the patient.
The association between obesity and attention-deficit hyperactivity disorder (ADHD) has been extensively reported in the literature. However, the potential mechanisms underlying this association are not completely understood. This study aimed to evaluate the association between body composition and ADHD and explore the possible genetic mechanisms involved.
View Article and Find Full Text PDFArticle Synopsis
- The study examined how the Val66Met polymorphism in the BDNF gene affects resilience in patients with major depressive disorder.
- Cognitive therapy not only improved resilience scores significantly but also reduced depressive symptoms over time.
- The findings suggest that genetic factors and gender play a role in resilience outcomes during cognitive treatment.