Background: Nanostructured surface modifications of Ti-based biomaterials are moving up from a highly-promising to a successfully-implemented approach to developing safe and reliable implants.
Methods: The study's main objective is to help consolidate the knowledge and identify the more suitable experimental strategies related to TiO nanotubes-modified surfaces. In this sense, it proposes the thorough investigation of two optimized nanotubes morphologies in terms of their biological activity (cell cytotoxicity, alkaline phosphatase activity, alizarin red mineralization test, and cellular adhesion) and their electrochemical behavior in simulated body fluid (SBF) electrolyte.
The composition of a commercial duplex stainless steel was modified with boron additions (3.5, 4.5, and 5.
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