Acute effects of peritoneal dialysis solutions in the mesenteric microcirculation.

Long-term peritoneal dialysis induces morphological changes that may lead to gradual functional impairment of the peritoneal membrane. These changes are characterized by progressive reduction in solute transport or ultrafiltration failure. The mechanism of the peritoneal response to dialysis fluids has not yet been fully elucidated.

Peritoneal transport after long-term exposure to Icodextrin in rats.

Background: Icodextrin, an effective osmotic substance that has been proposed as an alternative agent for peritoneal dialysis induces ultrafiltration over long dwells. This study examines the peritoneal transport after exposure to Icodextrin in rats.

Methods: Animals were divided in 4 groups and injected daily for 30 days with Icodextrin 7.