Isavuconazole Pharmacokinetics in Critically Ill Patients: Relationship with Clinical Effectiveness and Patient Safety.

Isavuconazole is used to treat fungal infections. This study aims to describe isavuconazole pharmacokinetics in critically ill patients and evaluate their relationship with clinical efficacy and patient safety. We conducted a prospective, observational study in patients treated with intravenous isavuconazole.

Network diffusion of gender diversity on boards: A process of two-speed opposing forces.

Network diffusion processes or how information spreads through networks have been widely examined in numerous disciplines such as epidemiology, physics, sociology, politics, or computer science. In this paper, we extend previous developments by considering a generalization of the diffusion by considering the possibility of differences in the speed of diffusion and reduction depending on the forces' directions. In this situation, the differential speed of diffusion produces deviations from the standard solution around the average of the initial conditions in the network.

Risk factors for mortality in patients with COVID-19 needing extracorporeal respiratory support.

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Networks of Boards of Directors: Is the 'Golden Skirts' Only an Illusion?

In this empirical research, using a database of 41,107 directors from 38 European countries from 1999 to 2015, we analyze the topological features of the director's networks and observe that the degree distribution for both men and women follows a power law. The exponent of the power law is higher for women than the one for men, suggesting a milder role of interlocking for women that points to the absence of the 'Golden Skirts' phenomenon at the European level (i.e.

Pharmacokinetics of Amikacin in Critical Care Patients on Extracorporeal Device.

In this study, we evaluate the effect of extracorporeal membrane oxygenation (ECMO) and ventricular assist devices (Levitronix) on the pharmacokinetic of amikacin in critically ill patients. Twelve patients with ECMO and three with Levitronix devices who started treatment with amikacin were included. Amikacin pre (Cmax) and post (Cmin) dose serum concentrations were measured during the first 72-96 hours of treatment initiation.

Estimating population ecology models for the WWW market: evidence of competitive oligopolies.

This paper proposes adapting a particle filtering algorithm to model online Spanish real estate and job search market segments based on the Lotka-Volterra competition equations. For this purpose the authors use data on Internet information searches from Google Trends to proxy for market share. Market share evolution estimations are coherent with those observed in Google Trends.

Systemic inflammatory response and increased risk for ventilator-associated pneumonia: a preliminary study.

Objective: Inflammatory markers have been assessed for the diagnosis and follow-up of ventilator-associated pneumonia (VAP), but their potential role in predicting the risk for VAP is unknown. We prospectively assessed the evolution of cytokines in mechanically ventilated patients and their predictive and diagnostic role for VAP.

Design: Prospective observational study.

Treatment of intra-abdominal bleeding with recombinant activated factor VII in a patient with disseminated intravascular coagulation secondary to septic shock.

Although mainly indicated for treatment of bleeding in haemophilia patients with inhibitors, recombinant activated factor VII (rFVIIa) has also been successfully used in other situations. However, no data are available on its use in the treatment of disseminated intravascular coagulation (DIC) secondary to septic shock. We report a man with DIC and septic shock due to retrocaecal appendicitis and severe intra-abdominal bleeding after surgery.