A fluorescent probe based on scopoletin-3-carboxylic acid: pH and micellization evaluation.

Coumarins are a class of compounds known for their synthetic and structural versatility, as well as their properties of great interest, such as biological and photophysical activities, and their application in the analysis of molecular microenvironments and their characteristics, such as pH. In this work, the synthesis of 7-hydroxy-6-methoxy-2-oxo-2H-chromene-3-carboxylic acid (3-SCA) was reported, and its absorption, emission and excitation spectral properties, along with photophysical properties such as molar absorption coefficient, lifetime, and Stokes Shift (Δν) in different solvents and pHs, were evaluated for the first time. High values of fluorescence quantum yield were observed for 3-SCA in solvents of different polarities, with a lifetime of approximately 5 ns.

First report on the electrooxidation of vinpocetine using a modification free sensing platform: application to pharmaceutical formulations.

This study presents the first insights into vinpocetine (VIN) behavior, a nootropic compound, on a glassy carbon electrode (GCE). Cyclic voltammetry (CV) revealed an irreversible oxidation peak at +1.0 V ( Ag/AgCl), with pH dependency indicating proton involvement in the electrochemical reaction.

Selenofuranoside improves long-term memory deficits in rats after exposure to monosodium glutamate: Involvement of Na, K-ATPase activity.

Monosodium glutamate (MSG) is the most widely used additive in the food industry; however, some adverse effects of this additive, including functional, learning, and behavioral alterations, have been observed in experimental animals and humans. Studies have shown learning and memory impairment in adult animals exposed to MSG. However, studies relating exposure to MSG to acetylcholinesterase (AChE) and Na, K-ATPase activities and memory damage are still scarce in the literature.

Selenofuranoside Ameliorates Memory Loss in Alzheimer-Like Sporadic Dementia: AChE Activity, Oxidative Stress, and Inflammation Involvement.

Alzheimer's disease (AD) is becoming more common due to the increase in life expectancy. This study evaluated the effect of selenofuranoside (Se) in an Alzheimer-like sporadic dementia animal model. Male mice were divided into 4 groups: control, Aβ, Se, and Aβ + Se.