Phaeofurans and sorbicillin analogues from a fungicolous Phaeoacremonium species (NRRL 32148).

Two new benzofuran-derived metabolites of polyketide origin called phaeofurans A and B (1 and 2), along with three sorbicillin analogues (3-5), have been obtained from a fungicolous isolate of the genus Phaeoacremonium (NRRL 32148). The structures were determined by analysis of MS and 2D NMR data. The antifungal effects of the extract were ascribed to the sorbicillin analogues.

Ophiocerins A-D and ophioceric acid: tetrahydropyran derivatives and an africane sesquiterpenoid from the freshwater aquatic fungus Ophioceras venezuelense.

Four new tetrahydropyran derivatives called ophiocerins A-D (1-4) and a new africane sesquiterpenoid (ophioceric acid; 5) have been isolated from cultures of the aquatic fungus Ophioceras venezuelense, together with the known compound regiolone. The structures and relative stereochemistry of these compounds were determined by analysis of 1D and 2D NMR data, while absolute stereochemical assignments for 1-4 were proposed by application of the exciton chirality CD method.

Cicadapeptins I and II: new Aib-containing peptides from the entomopathogenic fungus Cordyceps heteropoda.

Fermentation extracts of Cordyceps heteropoda (ARSEF #1880), an entomopathogenic fungus isolated from an Australian cicada, yielded a known antifungal compound, myriocin, and a complex microheterogeneous family of novel nonribosomal peptides, each containing two residues of alpha-aminoisobutyric acid (Aib). Structure elucidation of two major components of the peptide mixture, cicadapeptins I and II (1 and 2), was accomplished by amino acid analysis and various MS, 1-D NMR, and 2-D NMR experiments. Both compounds are acylated at the N-terminus by n-decanoic acid and amidated at the C-terminus by 1,2-diamino-4-methylpentane.