Transanal endoscopic microsurgery for rectal cancer. Long-term oncologic results.

Purpose: Local excision of malignant rectal tumors remains controversial due to the lack of prospective studies. The principal aim of this paper is to analyze survival and recurrence of patients with rectal cancer who were operated by transanal endoscopic microsurgery with curative intention.

Methods: In 1997, we started a prospective protocol for patients who had T1/T2 rectal tumors: transanal local full-thickness excision was considered curative in T1 low risk (group A); patients with T1 high-risk and T2 low-risk tumors received postoperative radiotherapy (group B).

Local full-thickness excision as first line treatment for sessile rectal adenomas: long-term results.

Objective: Removing rectal adenomas not only relieves symptoms, but also eradicates the incidence of carcinoma. There are many techniques for local removal of rectal polyps. Transanal endoscopic microsurgery (TEM) is the most recent.

Efficacy of orgotein in prevention of late side effects of pelvic irradiation: a randomized study.

Purpose: To study whether orgotein is effective in preventing late radiation-induced effects.

Methods And Materials: Patients >18 years old who were diagnosed with rectal cancer, had an indication for pelvic irradiation (RT) after surgery, and complied with the selection criteria were randomly assigned at the end of RT to receive orgotein for 7 weeks or no treatment (control). The Radiation Therapy Oncology Group toxicity scale was used to evaluate the RT-induced side effects for up to 2 years.

Postoperative radiochemotherapy in rectal cancer comparison of two combination schemes: alternating versus concomitant.

Aims And Background: To compare the results on disease control and toxicity of two different schedules of adjuvant combined treatment in advanced rectal cancer.

Methods: From January 1995 to September 1998, 127 patients with stage B2-C rectal cancer were treated with postoperative chemotherapy and radiotherapy with two different schemes: three cycles of 5-fluorouracil and leucovorin followed by pelvic radiotherapy and three weeks after radiation therapy was completed, another three cycles of chemotherapy were administered (alternating arm), or two cycles of 5-fluorouracil and leucovorin followed by concurrent radiochemotherapy and three weeks after ending another two cycles of 5-fluorouracil and leucovorin were administered (concomitant arm).

Results: Grade 3 acute toxicity was more frequent in the concomitant schedule group (33% vs 13%, P = 0.

The efficacy of orgotein in the treatment of acute toxicity due to radiotherapy on head and neck tumors.

Aims And Background: To assess the efficacy of orgotein in the treatment of acute secondary effects of radiotherapy on head and neck tumors.

Material And Methods: Data were collected on 41 patients who received radiotherapy for tumors of the head and neck. Radiotherapy was the exclusive treatment in 19.