Predictors of Respiratory Failure Development in a Multicenter Cohort of Inpatients With Cirrhosis.

Introduction: Hospitalized patients with cirrhosis can develop respiratory failure (RF), which is associated with a poor prognosis, but predisposing factors are unclear.

Methods: We prospectively enrolled a multicenter North American cirrhosis inpatient cohort and collected admission and in-hospital data (grading per European Association for the Study of Liver-Chronic Liver Failure scoring system, acute kidney injury [AKI], infections [admission/nosocomial], and albumin use) in an era when terlipressin was not available in North America. Multivariable regression to predict RF was performed using only admission day and in-hospital events occurring before RF.

Post-infantile giant cell hepatitis: A single center's experience over 25 years.

Background: Giant cell hepatitis in the adult population remains very poorly defined with only 100 case reports published in the literature over the last three decades.

Aim: To present our center's experience in an attempt to learn about the predisposing factors, outcomes and efficacy of proposed therapeutic interventions for giant cell hepatitis.

Methods: A retrospective chart review was conducted through the electronic records of the University of Pittsburgh Medical Center.

Incidence of Recurrent NASH-Related Allograft Cirrhosis.

Background: Cirrhosis secondary to nonalcoholic steatohepatitis (NASH) is projected to become the leading indication for liver transplantation (LT) in the USA in the next decade. The long-term implications of post-LT NASH, specifically on the development of allograft cirrhosis, are not well known.

Methods: A retrospective cohort of patients at a single large center undergoing LT for NASH from 2000 to 2015 was identified using a prospectively collected database.

2,4-Dichloro-benzaldehyde.

In the crystal structure of the title compound, C(7)H(4)Cl(2)O, the mol-ecules form a network of weak C-H⋯O inter-actions involving the aldehyde O atom and the ortho-H atom on the benzene ring together with C-H⋯O inter-actions between the formyl groups. Together, these connect the mol-ecules into (10) layers, which are stabilized additionally by π-π stacking inter-actions of the benzene rings [centroid-centroid distance = 3.772 (1) Å].