Novel antiangiogenic agents in dermatology.

Because angiogenesis underlies the pathogenesis of numerous conditions (cancer, psoriasis, macular degeneration), there is a pressing need for continued investigations into angiogenic signaling and potential drug targets. Antiangiogenic agents can be classified as either direct or indirect. Direct antiangiogenics act on untransformed endothelial cells to prevent differentiation and proliferation; indirect antiangiogenics act to inhibit factors involved in proangiogenic signaling.

Effectiveness of gentian violet and similar products commonly used to treat pyodermas.

The term pyoderma encompasses a variety of distinct entities including impetigo (bullous and nonbullous), erysipelas, cellulitis, folliculitis, and staphylococcal scalded skin syndrome. Treatment of pyodermas centers around wound care and appropriate antibiotic selection. Triphenylmethane dyes, such as gentian violet, represent a unique group of compounds that act as antiseptics and have shown clinical efficacy as antibiotics in a variety of pyodermas, including those secondary to methicillin-resistant Staphylococcus aureus.

Biomechanical properties of bone and cartilage in growing femoral head following ischemic osteonecrosis.

Legg-Calve-Perthes disease (LCPD) is one of the most common causes of a permanent deformity of the femoral head among pediatric hip disorders. Mechanical loading of the osteonecrotic femoral head undergoing repair is thought play a significant role in the development of the femoral head deformity. This study measured the mechanical properties in uniaxial unconfined compression tests of epiphyseal bone and cartilage from immature femoral heads following surgical induction of osteonecrosis using an established piglet model.