Brazilian Society of Angiology and Vascular Surgery guidelines on peripheral artery disease.

Patients with peripheral artery disease and generalized atherosclerosis are at high risk of cardiovascular and limb complications, affecting both quality of life and longevity. Lower limb atherosclerotic disease is associated with high cardiovascular morbidity and mortality and adequate management is founded on treatments involving patient-dependent factors, such as lifestyle changes, and physician-dependent factors, such as clinical treatment, endovascular treatment, or conventional surgery. Medical management of peripheral artery disease is multifaceted, and its most important elements are reduction of cholesterol level, antithrombotic therapy, control of arterial blood pressure, control of diabetes, and smoking cessation.

In vitro antimicrobial, antibiofilm photodynamic activity, and molecular dynamic simulations of tetra-cationic porphyrinmembrane interactions against foodborne microorganisms.

This manuscript presents a new report on the in vitro antimicrobial photo-inactivation of foodborne microorganisms (Salmonella spp. and Listeria monocytogenes) using tetra-cationic porphyrins. Isomeric tetra-cationic porphyrins (3MeTPyP, 4MeTPyP, 3PtTPyP, and 4PtTPyP) were tested, and antimicrobial activity assays were performed at specific photosensitizer concentrations under dark and white-light LED irradiation conditions.

The First Report of In Vitro Antifungal and Antibiofilm Photodynamic Activity of Tetra-Cationic Porphyrins Containing Pt(II) Complexes against for Onychomycosis Treatment.

Onychomycosis is a prevalent nail fungal infection, and is one of the most common microorganisms associated with it. One alternative therapy to the conventional treatment of onychomycosis is antimicrobial photoinactivation. This study aimed to evaluate for the first time the in vitro activity of cationic porphyrins with platinum(II) complexes and against .

Primary infectious aortic aneurysm: a case series and review of the literature.

Infectious aneurysms, formerly known as mycotic aneurysms, are rare, most often involve the aorta in young patients, and have a greater tendency to rupture than aneurysms of other etiologies. The most characteristic shape is saccular and the most common etiologic agents are and . There is scant and imprecise information in the literature about correct nomenclature, diagnosis, and treatment.

Host species and environment drivers of ectoparasite community of rodents in a Mojave Desert wetlands.

Drivers of patterns of ectoparasitism in rodents in patchy Mojave Desert wetlands were investigated. A total of 1,571 ectoparasites in Mesostigmata, Trombidiformes, Siphonaptera and Ixodida were collected from 341 rodents (Microtus californicus scirpensis, Mus musculus, Reithrodontomys megalotis, Peromyscus eremicus, and Neotoma lepida) at eleven marshes. Trombiculids accounted for 82.

Dyspnoea at the end of life: instrument development and validation-the CONFORTO Strategy.

Objective: To describe the construction and validation of the algorithm for riteria for inclusion; bjective of dyspnoea; otification of patient/family/health professionals; acial air flow; xygen; elaxion and breathing; reating causes of dyspnoea and pioid (CONFORTO), an instrument to guide health professionals in managing dyspnoea in patients with an advance stage of the disease at the end-of-life.

Methods: The study was carried out in three stages: (1) literature review and construction of CONFORTO; (2) semantic validation; (3) application of the CONFORTO Strategy to health professionals as a test (before video lessons) and post-test (20 days after watching video lessons) methodology. The scores obtained in the pretest and post-test were compared using the Wilcoxon test.

Stabilization of Magnetic Skyrmions on Arrays of Self-Assembled Hexagonal Nanodomes for Magnetic Recording Applications.

Magnetic skyrmions are nontrivial spin textures that resist external perturbations, being promising candidates for the next-generation recording devices. Nevertheless, a major challenge in realizing skyrmion-based devices is the stabilization of ordered arrays of these spin textures under ambient conditions and zero applied field. Here, we demonstrate for the first time the formation and stabilization of magnetic skyrmions on the arrays of self-assembled hexagonal nanodomes taking advantage of the intrinsic properties of its curved geometry.

Optimization of River Sampling: Application to Nutrients Distribution in Tagus River Estuary.

The assessment of river water pollution trends is affected by the seasonal variation of river conditions, the variability of pollution sources, the heterogeneity of pollutants distribution, the representativeness/uncertainty of sampling, and the uncertainty of sample analysis. This work presents a methodology to model the uncertainty of river water sampling based on available information about the spatial distribution of the studied parameter in the river. The uncertainty from "single sampling" (SS) or by production of a composite sample by mixing m subsamples collected randomly (RS) or in a line that crosses the sampling circle (LS) was studied.

Effects of weekly LED therapy at 625 nm on the treatment of chronic lower ulcers.

The aim of this study was to evaluate the effects of LED therapy associated with compression therapy on chronic venous leg ulcers (CVUs). The study included CVU patients (n = 17, eight men) who were eligible for Unna's boot treatment. Ulcers were treated on a weekly basis with either LED therapy (625 nm, 4 J/cm(2)) and an Unna's boot (LED ulcers, n = 14) or a placebo treatment and an Unna's boot (control ulcers, n = 14).

Chromosomal heterogeneity and instability characterize pediatric medulloblastoma cell lines and affect neoplastic phenotype.

Chromosomal heterogeneity is a hallmark of most tumors and it can drive critical events as growth advantages, survival advantages, progression and karyotypic evolution. Medulloblastoma (MB) is the most common malignant central nervous system tumor in children. This work attempted to investigate chromosomal heterogeneity and instability profiles of two MB pediatric cell lines and their relationship with cell phenotype.

Pulmonary metastases in men: primary tumor in an unusual location.

We report a case of breast cancer identified in a 72-year-old male as an accidental finding during the course of the investigation of a primary tumor and the search for pulmonary metastases. We address aspects related to the epidemiology, diagnosis, treatment and prognosis of this condition in males.