Synthetic beidellite clay as nanocarrier for delivery of antitumor oxindolimine-metal complexes.

Studies on the immobilization of oxindolimine‑copper(II) or zinc(II) complexes [ML] in synthetic beidellite (BDL) clay were developed to obtain a suitable inorganic carrier capable of promoting the modified-release of metallopharmaceuticals. Previous investigations have shown that the studied metal complexes are promising antitumor agents, targeting DNA, mitochondria, and some proteins. They can bind to DNA, causing oxidative damage via formation of reactive oxygen species (ROS).

Desferrioxamine-cadmium as a 'Trojan horse' for the delivery of Cd to bacteria and fungi.

Molecules naturally designed for the acquisition of essential metals can be used as a shuttle to deliver toxic metal ions to target organisms. In this study, we describe for the first time the synthesis of a derivative of cadmium and desferrioxamine B, a bacterial siderophore. The new compound was characterized by elemental analysis, vibrational (infrared and Raman) spectroscopy, mass coupled thermal analyses and X-ray diffraction methods.