Publications by authors named "Ricardo A Rendon"
Article Synopsis
- - Abiraterone acetate, apalutamide, darolutamide, and enzalutamide are androgen receptor axis-targeted therapies (ARATs) used to treat prostate cancer, often alongside oral antithrombotic therapies, which may lead to significant drug-drug interactions.
- - A multidisciplinary expert panel used a modified electronic Delphi process to reach consensus on which ARAT/antithrombotic pairs should be monitored and how to manage these interactions, ultimately recommending avoiding 11 pairs and modifying therapy for 8 others.
- - This process underscores the need for more research into the clinical outcomes of ARAT and antithrombotic interactions while providing clinicians with actionable guidance for safer therapeutic choices. *
Introduction: In 2019, our center attempted to transition all partial nephrectomies (PNs) to robotic-assisted laparoscopic PN (RALPN). The purpose of this study was to compare RALPN outcomes to laparoscopic PN (LPN) and open PN (OPN) at our institution, as there is limited literature from Canadian centers.
Methods: In this single-center, two-surgeon, retrospective cohort study, we compared RALPN outcomes during the early phase of our robotics program to OPN and LPN performed just before the introduction of RALPN.
Article Synopsis
- There's a meeting called the Canadian Consensus Forum (CCF3) where doctors talked about how to manage prostate cancer (PCa) better.
- They discussed important topics like treatment options and how to test for the disease using new technology.
- The doctors agreed on more than half of the questions discussed, helping to guide future treatment and research to improve care for patients with prostate cancer.
Introduction: Neoadjuvant chemotherapy (NAC) is the standard of care for patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC); however, NAC can be associated with significant side effects and morbidity in some patients. NAC may contribute to sarcopenia, obesity, and the combination of the two. Our study examined the effects of NAC on body composition and the association between body composition and adverse events.
View Article and Find Full Text PDFIntroduction: Patients undergoing radical nephrectomy (RN) are often admitted with protocolized bloodwork for several days following their operation, yet the clinical value of serial hemoglobin (Hgb) measurements has not been established. This can lead to unnecessary costs and can prolong patient stay, despite the absence of an intervention based on these lab values. This study sought to examine perioperative Hgb values and identify those patients at high risk of bleeding requiring intervention, as well as those patients who are unlikely to require further monitoring.
View Article and Find Full Text PDFIntroduction: Robotic surgery is used in the treatment of kidney tumors. We aimed to determine if robotic access was associated with initial choice of management for patients with a clinical stage I kidney mass.
Methods: Patients with a clinical stage I kidney mass were identified from the Canadian Kidney Cancer information system (CKCis) cohort.
Introduction: Androgen deprivation therapy (ADT) with androgen receptor axis-targeted (ARAT) therapy is the standard of care provided to patients with metastatic prostate cancer. While effective, it results in sequelae, such as loss of skeletal muscle mass. In this study, we compared the sarcopenic effects of abiraterone and enzalutamide, two ARATs used to treat metastatic prostate cancer.
View Article and Find Full Text PDFArticle Synopsis
- * A survey conducted among 38 investigators at 22 sites revealed that while most recognize the importance of genetic testing in advanced cases, access issues and uncertainties hinder broader implementation.
- * The researchers recommend developing an algorithm to guide healthcare providers in determining when and how to perform genetic testing for prostate cancer patients, aiming to improve access and clarity in testing practices.
Introduction: Radical cystectomy (RC) is associated with high rates of morbidity, prolonged hospital stay, and increased opioid use for postoperative pain management; however, the relationship between postoperative opioid use and length of stay (LOS ) remains uncharacterized. This study serves to investigate the association between postoperative opioid use and length of hospital stay after RC. The relationship between patient and surgical factors on LOS was also characterized.
View Article and Find Full Text PDFIntroduction: Genetic testing in advanced prostate cancer is rapidly moving to become standard of care. Testing for genetic alterations in genes involved in DNA repair pathways, particularly those implicated in the homologous recombination repair (HRR) pathway, in patients with metastatic prostate cancer (mPCa) can inform selection of optimal therapies, as well as provide information about familial cancer risks; however, there are currently no consistent Canadian guidelines in place for genetic testing in mPCa.
Methods: A multidisciplinary steering committee guided the process of an environmental scan to define the current landscape, as well as the perceived challenges, through interviews with specialists from 14 sites across Canada.
Introduction: Routine measurements of serum hemoglobin (sHgb) are common after abdominal surgery; however, prolonged measurements may be associated with patient anxiety, increased costs, and longer hospitalization without clinical benefit. The objective of this study was to determine the utility of routine sHgb measurements after radical cystectomy (RC) and factors associated with transfusion of packed red blood cell (pRB C) beyond postoperative day (POD ) 2.
Methods: We retrospectively reviewed patients who underwent RC between 2009 and 2019 at a single academic tertiary care center.