[Pleuro-pericarditis developed under a leflunomide therapy].

Leflunomide is an immunosuppressant drug used in rheumatoid arthritis and psoriatic arthritis. This product may cause rare but serious interstitial lung disease that appear at the beginning of treatment. This is why leflunomide should be prescribed and monitored in hospital.

[Cleft lip and palate treatment in the plastic surgery department in the university hospital center in Lille].

The aim of cleft care is to favor a normal socialization of patients with fewer therapeutic coercion. It supposes a full multidisciplinary team including psychologist, speech therapeutic, dental orthopedist, oto-rhino-laryngologist and surgeons. All of them have to be well trained which supposes a sufficient amount of cases: anglo-saxon studies have proven that a mean of at least 20 new cases per year of primary cleft were necessary.

[Long-term treatment of Alzheimer's disease: followup of a cohort of 255 patients treated with lacrine for four years].

We describe the follow-up of a cohort of 255 Alzheimer's disease (AD) patients (81 males, 174 females) treated by tacrine during 4 years. We performed the survey of hepatic, cholinergic and general tolérance. Drug efficacy was measured by MMS examination on weeks 0, 18, 30, 52, 104, 156 and 208.

Orodigitofacial syndromes type I and II: clinical and surgical studies.

Eleven patients were followed at the multidisciplinary facial cleft department from 1963 to 1993. Nine had orodigitofacial (ODF) I syndrome (Papillon-Leage, 1954) and two had ODF II syndrome (Mohr, 1941). The authors observed seven median clefts of the upper lip, eight atypical cleft palates, nine lingual tumors, ten polylobed tongues, four ankyloglossia.

[Bone age and maxillo-mandibular dysharmony in children with cleft lip and palate].

The clinical examination, the bone age and the palatine surgical trauma served to evaluate the factors producing maxillo-mandibular dysharmonies in cleft lip/palate patients. 55 patients with total unilateral cleft lip and palate aged from 10 months to 13 years were used for this study. By clinical examination the patients were divided in: group A--37 cases without dysharmonies and B--18 cases with dysharmonies.

[Rotation flap from the anterior tonsillar pillar for the reconstruction of the intermaxillary commissure and posterior portion of the cheek].

A modified technique is presented, which is based on Kazanjian and Hynes' methods using a lateral pharyngeal flap, and which provides a simple means of repair of loss of mucosal substance from the intermaxillary area or the posterior two-thirds of the cheek.