[The increase in the proportion of nervous animals bred for catatonia: the participation of central adrenoreceptors in catatonic reactions].

Using a large amount of breeding material, the idea of D. K. Belyaev on the role of selection in the appearance of new behavioral and neuronal forms was confirmed.

[Renin-angiotensin system gene expression in the kidney and in the heart in hypertensive ISIAH rats].

The content of mRNA of renin-angiotensin system (RAS) genes in the kidney and heart of hypertensive ISIAH and normotensive WAG rats was measured by the real-time PCR. Statistically significant decrease of RAS gene mRNA was registered in the kidney of ISIAH rats, including Ren (by 45%), Ace (43%), AT1A (34%), COX-2 (50%). In the myocardium AT1A mRNA expression decreased by 28% while Ace mRNA expression increased by 80%.

[Learning of rats predisposed to catalepsy in Morris water test].

It was shown that GC rats predisposed to catalepsy do not differ from Wistar rats in success rate or latency (time of finding of the hidden escape platform) in the Morris water test. However, unlike Wistar, GC rats are inclined to passive drift and longer floating episodes. Rats of the MD+ strain predisposed to hyperkinesis in the form of horizontal pendulum-like movements of the head and upper limb girdle show longer latency and lower rate of successful trials than Wistar or MD-, rats selected for absence of the pendulum-like movements.

[Typological characteristics of behavior in strains of rats bred for enhancement and absence of pendulum movements. Association with brain monoamines].

Typological characteristics of behavior were studied in rats bred for enhancement (PM+) and absence (PM-) of pendulum movements. Excitement in different test situations was manifest in PM+ rats, whereas passive defensive reactions were characteristic of PM- rats. Increased excitability of PM+ rats was expressed in their greater predisposition to audiogenic epilepsy (83% in PM+ versus 40% in PM- rats).