[Novel method of analysis of risk of development of ischemic heart disease with the use of genomic and computer technologies].

Aim: to assess effectiveness of the use of modern methods of prognostication for assessment of risk of development of ischemic heart disease (IHD).

Material And Methods: We examined 131 patients with diagnosis of IHD verified by coronary angiography and 159 subjects of control group. Initial information on each patient included the following parameters: traditional risk factors, laboratory parameters, results of instrumental examination, genetic markers.

[Long-term results of conservative treatment of pyo-destructive diseases of the lungs and parapneumonic empyema].

An analysis of results and treatment outcomes of 178 patients has been made. The patients were examined 1, 3, 6, 12, 24 months after discharge from hospital. The parameters characterizing residual cavities, pneumofibrosis, pleural fibrosis and changes in the bronchial tree were analyzed.

[Prediction of outcomes of surgical treatment of degenerative lumbar disk disease].

The paper focuses on algorithms of outcomes assessment of surgical treatment of the patients with degenerative lumbar disk disease. From 1997 to 2006 389 patients with discogenic lumbar pain were operated in the Medical Center of Central Bank of Russia. 185 patients underwent radiofrequency destruction of facet nerves, laser percutaneous lumbar discectomy was performed in 39 patients, microdiscectomy -- in 131, and decompression combined with lumbar spine stabilization -- in 31 cases.

[Biologic markers and occupational monitoring of human exposure to exhaust gases of diesel engines].

The article presents results of studies covering changes in porphyrin and heme synthesis in lymphocytes of miners exposed to exhaust gases of diesel engines.

[Using CAREX data base system for occupational exposure to carcinogens in Estonia].

CAREX (CARcinogen EXposure) is international information system on occupational exposure to know and suspected carcinogens. The CAREX database provides selected exposure data and documented estimates of the number of exposed by workers by country, carcinogen, and industry. CAREX includes data on 139 agents evaluated by the International Agency for Research on Cancer, displayed across the 55 industrial classes of the United Nations system (ISIC Revision 2).

[The use of tranexamic acid as an anesthetic component in ENT surgeries in patients with high surgical-anesthetic risk and in hemorrhagic shock intensive therapy].

Experimental and clinical trials have shown that anesthesia and intensive therapy of shock incorporating tranexamic acid enhance analgesia, hyporeflexia, thus ensuring stable, adequate anesthesia which is safe under reduced doses of standard anesthesiological modalities. Application of tranexamic acid provided more favourable course of postanesthesiological and postoperative periods, decreased the number of complications and lethal outcomes compared to standard anesthesia.

[Use of nonopiate agents for anesthesia in ENT patients at high surgical-anesthesiological risk].

Optimal methods of endotracheal anesthesia using non-opiate drugs of four classes (clofelin, transamine, contrykal, ketanes) have been fundamentally grounded developed and tried in extensive and traumatic operations for ENT malignant and vascular tumors as well as inflammation in patients of high anesthesiological operative risk. The drugs were used in 174 patients including 13 children. 87.

[Study of the role of parents' occupation in children's mortality].

This study have been carried out to: a) investigate the prevalence of such occupational factors in parents which could be fatal to their children, and b) evaluate quantitatively the risk of mortality in infants caused by some leading diseases developed as a result of harmful occupational factors to which their parents had been exposed. During this work the data bank on infant mortality in Tallinn based on deaths registration in city archive for period 1968-1992 has been created. This bank includes the data on parents' occupation.

[Leukocytic shifts following pancreatic resection with a plasma scalpel and cryodestruction].

Two series of experiments were carried out on dogs. In the first series, blood leukocytes count was studied after resection of the pancreas using plasma scalpel. The resection caused two-phase leukocyte reaction: neutrocytosis (phase I) and leukocytosis involving mainly lymphocytes and monocytes (phase II).

[Deamination reactions involving several nitrogen compounds and mammalian radioresistance].

Inhibition of monoamine oxidase (substrates tyramine or serotonin) with simultaneous appearance of diamine oxidase (substrates histamine or putrescine) and distinct increase in AMP-deaminating activities were found after total body X-ray irradiation (700 r) of white mice or rats in mitochondrial fractions isolated from their liver and intestines. These impairments in deamination of nitrogenous compounds in liver mitochondria of guinea pigs, which are must less radioresistant as compared with mice or rats, were noted after the irradiation at a dose 300 r, but in the liver mitochondria of mongolian gerbyls (Mariones unguiculatus), which are highly radioresistant, the irradiation even at a dose 1500 r did not cause appearance either of histamine or of AMP-deaminating activities while the decrease in the monoamine oxidase activity was not statistically significant. Feeding to the mice the grasses, which comprize the fodder of mongolian gerbyls under natural conditions, increased radioresistance of the animals and prevented at the same time appearance in the mitochondrial fractions of liver and intestines of those impairments in deamination of nitrogenous compounds which accompanied development of irradiation injuries.