Publications by authors named "Ria Zalfen"
Article Synopsis
- Neutrophils are crucial in the process of tissue injury and healing, and studying their behavior can provide insights into cardiovascular issues.
- A new non-invasive imaging technique using fluorine-loaded nanotracers allows researchers to track neutrophil activity in real-time throughout the body.
- This method helps identify sources of inflammation and could improve understanding of cardiovascular diseases by monitoring neutrophil activation and infiltration in both sterile and bacterial infections.*
In the adult heart, the epicardium becomes activated after injury, contributing to cardiac healing by secretion of paracrine factors. Here, we analyzed by single-cell RNA sequencing combined with RNA in situ hybridization and lineage tracing of Wilms tumor protein 1-positive (WT1) cells, the cellular composition, location, and hierarchy of epicardial stromal cells (EpiSC) in comparison to activated myocardial fibroblasts/stromal cells in infarcted mouse hearts. We identified 11 transcriptionally distinct EpiSC populations, which can be classified into three groups, each containing a cluster of proliferating cells.
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