Long-term outcomes of heparin-induced thrombocytopenia after cardiac surgery.

Objective: Heparin-induced thrombocytopenia (HIT) after cardiac surgery may lead to greater morbidity and mortality than predicted preoperatively. The aim of this study is to assess long-term outcomes of patients surviving HIT after cardiac surgery.

Methods: Single-institution, retrospective study of adult patients who underwent cardiac surgery between 2011 and 2023 and developed HIT postoperatively.

Infection preventionists' experiences and perceptions of health equity and the development of health care-associated infections: Focus group findings conducted from the Association for Professionals in Infection Control and Epidemiology (APIC) members.

Background: Health equity is a growing concern in health care. Infection prevention and control (IPC) practices can play a pivotal role in addressing inequities related to health care-associated infections (HAIs). The authors aimed to explore the intersection of health equity and IPC practices.

'Donor-acceptor', 'interpenetrating polymer network' and 'electrostatic self-assembly' work in tandem to achieve extraordinary specific shielding effectiveness.

The exploration of 'electrostatic self-assembly' on solid surfaces has garnered significant interest across various fields. With the sophistication of gadgets, managing electromagnetic interference (EMI) from stray signals, especially in stealth applications, necessitates materials that can absorb microwaves. A promising approach involves integrating lightweight self-healing polymeric materials.

Unraveling Dilemmas and Lacunae in the Escalating Drug Resistance of to Bedaquiline, Delamanid, and Pretomanid.

Delamanid, bedaquiline, and pretomanid have been recently added in the anti-tuberculosis (anti-TB) treatment regimens and have emerged as potential solutions for combating drug-resistant TB. These drugs have proven to be effective in treating drug-resistant TB when used in combination. However, concerns have been raised about the eventual loss of these drugs due to evolving resistance mechanisms and certain adverse effects such as prolonged QT period, gastrointestinal problems, hepatotoxicity, and renal disorders.

A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer.

A key role in lessening humanity's continuous fight against cancer could be played by photodynamic therapy (PDT), a minimally invasive treatment employed in the medical care of a range of benign disorders and malignancies. Cancerous tissue can be effectively removed by using a light source-excited photosensitizer. Singlet oxygen and reactive oxygen species are produced the photosensitizer as a result of this excitation.

Transcriptional Profiling and Consensus Molecular Subtype Assignment to Understand Response and Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Colorectal Cancer.

Purpose: Activating mutations in , , and are known to cause resistance to anti-epidermal growth factor receptor (EGFR) therapy; however, only approximately 40% of patients with colorectal cancer (CRC) with tumors respond to anti-EGFR treatment. We sought to discover novel biomarkers to predict response to anti-EGFR antibody treatment in CRC and to understand mechanisms of resistance to anti-EGFR therapy.

Materials And Methods: Transcriptomic profiles from three clinical and two preclinical cohorts treated with cetuximab were used to assign consensus molecular subtypes (CMS) to each sample and correlated with outcomes.

Going beyond Cellulose and Chitosan: Synthetic Biodegradable Membranes for Drinking Water, Wastewater, and Oil-Water Remediation.

Membrane technology is an efficient way to purify water, but it generates non-biodegradable biohazardous waste. This waste ends up in landfills, incinerators, or microplastics, threatening the environment. To address this, research is being conducted to develop compostable alternatives that are sustainable and ecofriendly.

Adamantoid Scaffolds for Multiple Cargo Loading and Cellular Delivery as β-Cyclodextrin Inclusion Complexes.

There is huge demand for developing guests that bind β-CD and can conjugate multiple cargos for cellular delivery. We synthesized trioxaadamantane derivatives, which can conjugate up to three cargos per guest. H NMR titration and isothermal titration calorimetry revealed these guests form 1 : 1 inclusion complexes with β-CD with association constants in the order of 10  M .

On the role of wall thickness in determining the plasmonic properties of silver-gold nanocages.

This work examines the roles played by wall thickness in determining the plasmonic properties of gold-silver (Ag-Au) nanocages. Ag-Au cages with different wall thicknesses, but the same void or outer size, shape, and elemental composition, were designed as a model platform. The experimental findings were understood with theoretical calculations.

Fundamental Understanding of Ultrathin, Highly Stable Self-Assembled Liquid Crystalline Graphene Oxide Membranes Leading to Precise Molecular Sieving through Non-equilibrium Molecular Dynamics.

Self-assembled graphene oxide lyotropic liquid crystal (GO LLC) structures are mostly formed in aqueous medium; however, most GO derivatives are water insoluble, so processing GO LLCs in water poses a practical limitation. The use of polar aprotic solvent (like dimethyl sulfoxide) for the formation of GO LLC structures would be interesting, because it would allow incorporating additives, like photoinitiators or cross-linkers, or blending with polymers that are insoluble in water, which hence would expand its scope. The well-balanced electrostatic interaction between DMSO and GO can promote and stabilize the GO nanosheets' alignment even at lower concentrations.

Interpenetrating polymer networks for desalination and water remediation: a comprehensive review of research trends and prospects.

Interpenetrating polymer network (IPN) architectures have gained a lot of interest in recent decades, mainly due to their wide range of applications including water treatment and environmental remediation. IPNs are composed of two or more crosslinked polymeric matrices that are physically entangled but not chemically connected. In polymer science, the interpenetrating network structure with its high polymer chain entanglement is commonly used to generate materials with many functional properties, such as mechanical robustness and adaptable structure.

Assessment of quality and reliability of YouTube videos for patient and physician education on inflammatory myositis.

Introduction: YouTube is the second most popular search website worldwide to access health information online. This study was undertaken to assess the reliability and quality of information about myositis on YouTube and delineate attributes of useful videos using standard metrics.

Methods: We conducted a thorough search on YouTube using 9 search terms related to myositis.

Silver-mediated Room Temperature Reactions for the Synthesis of -α-Ketoacyl Sulfoximines and -α,β-Unsaturated Acyl Sulfoximines.

Here, we report a silver-mediated coupling of acetylenes with sulfoximines to synthesize -α-ketoacyl sulfoximines and -α,β-unsaturated acyl sulfoximines. The reactions are performed under an open atmosphere using the oxidant KSO and the ligand 2,2-bipyridyl. However, the fate of the product formation is controlled by the type of substrate used.

Polyoxometalate-immobilized carbon nanotube constructs triggered by host-guest assembly result in excellent electromagnetic interference shielding.

In the era of fifth-generation networks and the Internet of Things, new classes of lightweight, ultrathin, and multifunctional electromagnetic interference (EMI) shielding materials have become inevitable prerequisites for the protection of electronics from stray electromagnetic signals. In the present study, for the first time, we have designed a unique nanohybrid composed of a copper-based polyoxometalate (Cu-POM)-immobilized carbon nanotube construct, having a micron (∼100 μm)-level thickness, through a facile vacuum-assisted filtration technique. In this course of study, a total of four Cu-POMs, two from each category of Keggin and Anderson bearing opposite charges, , positive and negative, have been rationally selected to investigate the effects of the host-guest electrostatic interaction between CNT and POMs in the EMI shielding performance.

A universal approach to 'host' carbon nanotubes on a charge triggered 'guest' interpenetrating polymer network for excellent 'green' electromagnetic interference shielding.

The widespread use of miniaturized electronic gadgets today faces stiff reliability obstacles from factors like stray electromagnetic signals. The challenge is to design lightweight shielding materials that combine small volume and high-frequency operations to reliably reduce/eliminate electromagnetic interference. Herein, in the first of its kind, a sequential interpenetrating polymeric network (IPN) membrane was used to host a CNT construct through a stimuli-responsive trigger.

Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder.

The smoothened sonic hedgehog (Smo-Shh) pathway is one mechanism that influences neurogenesis, including brain cell differentiation and development during childhood. Shh signaling dysregulation leads to decreased target gene transcription, which contributes to increased neuronal excitation, apoptosis, and neurodegeneration, eventually leading to neurological deficits. Neuropsychiatric disorders such as OCD and related neurological dysfunctions are characterized by neurotransmitter imbalance, neuroinflammation, oxidative stress, and impaired neurogenesis, disturbing the cortico-striato-thalamo-cortical (CSTC) link neuronal network.

deepGraphh: AI-driven web service for graph-based quantitative structure-activity relationship analysis.

Artificial intelligence (AI)-based computational techniques allow rapid exploration of the chemical space. However, representation of the compounds into computational-compatible and detailed features is one of the crucial steps for quantitative structure-activity relationship (QSAR) analysis. Recently, graph-based methods are emerging as a powerful alternative to chemistry-restricted fingerprints or descriptors for modeling.

TCT-mediated click chemistry for the synthesis of nitrogen-containing functionalities: conversion of carboxylic acids to carbamides, carbamates, carbamothioates, amides and amines.

Here, we report a -trichlorotriazine (TCT, also known as cyanuric chloride) mediated one-pot general method for the conversion of carboxylic acids into ubiquitous functionalities such as carbamides, carbamates, carbamothioates, amides, and amines. The TCT-mediated activation of acids followed by azidation and heating led to the isocyanate formation Curtius rearrangement which involves click chemistry in the presence of nucleophiles and provided the coupled product. The TCT was employed at ≤40 mol% with respect to the starting materials; however, its bulk availability and low cost provide a unique opportunity towards its applicability in the synthesis of functional molecules.

Functionalized Nitroimidazole Scaffold Construction and Their Pharmaceutical Applications: A 1950-2021 Comprehensive Overview.

Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from with antibacterial activity, which was later identified as Azomycin (2-nitroimidazole) and remained in focus until now.

Smo-Shh Agonist Purmorphamine Prevents Neurobehavioral and Neurochemical Defects in 8-OH-DPAT-Induced Experimental Model of Obsessive-Compulsive Disorder.

Obsessive-compulsive disorder is a mental disorder characterized by repetitive, unwanted thoughts and behavior due to abnormal neuronal corticostriatal-thalamocortical pathway and other neurochemical changes. Purmorphamine is a smoothened-sonic-hedgehog agonist that has a protective effect against many neurological diseases due to its role in maintaining functional connectivity during CNS development and its anti-inflammatory and antioxidant properties. As part of our current research, we investigated the neuroprotective effects of PUR against behavioral and neurochemical changes in 8-hydroxy-2-(di-n-propylamino)-tetralin-induced obsessive-compulsive disorder in rats.

OdoriFy: A conglomerate of artificial intelligence-driven prediction engines for olfactory decoding.

The molecular mechanisms of olfaction, or the sense of smell, are relatively underexplored compared with other sensory systems, primarily because of its underlying molecular complexity and the limited availability of dedicated predictive computational tools. Odorant receptors (ORs) allow the detection and discrimination of a myriad of odorant molecules and therefore mediate the first step of the olfactory signaling cascade. To date, odorant (or agonist) information for the majority of these receptors is still unknown, limiting our understanding of their functional relevance in odor-induced behavioral responses.

An Integrated Guide for Designing Video Abstracts Using Freeware and Their Emerging Role in Academic Research Advancement.

Video abstracts (VAs) are a motion picture equivalent of written abstracts. With greater use of social media platforms for post publication promotions of research articles, VAs have gained increasing popularity among researchers in recent years. Widespread lockdowns and social distancing protocols in the pandemic period furthered the use of VAs as a tool for efficient learning.

Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain.

Multiple Sclerosis (MS) is a progressive neurodegenerative disease with clinical signs of neuroinflammation and the central nervous system's demyelination. Numerous studies have identified the role of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) overexpression and the low level of peroxisome proliferator-activated receptor-gamma (PPAR-γ) in MS pathogenesis. Guggulsterone (GST), an active component derived from 'Commiphora Mukul,' has been used to treat various diseases.

The ubiquitin ligase FBXW7 targets the centriolar assembly protein HsSAS-6 for degradation and thereby regulates centriole duplication.

Formation of a single new centriole from a pre-existing centriole is strictly controlled to maintain correct centrosome number and spindle polarity in cells. However, the mechanisms that govern this process are incompletely understood. Here, using several human cell lines, immunofluorescence and structured illumination microscopy methods, and ubiquitination assays, we show that the E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (FBXW7), a subunit of the SCF ubiquitin ligase, down-regulates spindle assembly 6 homolog (HsSAS-6), a key protein required for procentriole cartwheel assembly, and thereby regulates centriole duplication.