Publications by authors named "Ri-Xin Zheng"
Article Synopsis
- Osteogenic differentiation of mesenchymal stem cells (MSCs) is influenced by various mechanisms, with ubiquitin-dependent protein degradation playing a key role.
- The study identifies USP34 as a crucial regulator of this differentiation; its expression increases when MSCs are induced to differentiate, and its loss inhibits this process.
- USP34 is shown to stabilize proteins Smad1 and RUNX2, essential for bone formation, and its absence leads to lower bone mass in mice and impaired bone regeneration.
