Publications by authors named "Rhys Izuagbe"
The cGAS-STING pathway is central to the interferon response against DNA viruses. However, recent studies are increasingly demonstrating its role in the restriction of some RNA viruses. Here, we show that the cGAS-STING pathway also contributes to the interferon response against noroviruses, currently the commonest causes of infectious gastroenteritis worldwide.
View Article and Find Full Text PDFExpanding the arsenal of prophylactic approaches against SARS-CoV-2 is of utmost importance, specifically those strategies that are resistant to antigenic drift in Spike. Here, we conducted a screen of over 16,000 RNAi triggers against the SARS-CoV-2 genome, using a massively parallel assay to identify hyper-potent siRNAs. We selected Ten candidates for in vitro validation and found five siRNAs that exhibited hyper-potent activity (IC50 < 20 pM) and strong blockade of infectivity in live-virus experiments.
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on understanding how SARS-CoV-2 spreads in higher education environments, specifically at the University of Cambridge, to help protect students and vulnerable populations.
- Researchers sequenced 482 virus samples from the university and compared them with 972 samples from the local community, finding that most cases were linked to a specific social gathering rather than multiple virus strains.
- The study revealed that while transmission occurred significantly within student accommodations and classes, targeted infection control measures and a national lockdown were effective in managing the spread.