P2Y12 inhibitors in cardiovascular disease: focus on prasugrel.

Objective: To review the literature describing the pharmacology, pharmacokinetic properties, efficacy, and adverse effects of prasugrel, a new thienopyridine.

Data Sources: A literature search was conducted (1966-November 2008) of the MEDLINE, Current Contents, EMBASE, and International Pharmaceutical Abstract databases using the key words prasugrel, CS-747, LY640315, and P2Y(12). Bibliographies of identified literature were also reviewed for additional references.