Publications by authors named "Rhonda Holgate"
Article Synopsis
- Deep skin wounds are serious and often need special skin grafts to heal properly.
- A new method using human skin cells can take less skin from donors and still help healing, but old skin cells don’t work as well.
- Researchers found that adding a special ingredient called hTERT to skin cells can help them grow better and heal faster in tests with mice.
Aims: Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated ageing syndrome associated with premature vascular disease and death due to heart attack and stroke. In HGPS a mutation in lamin A (progerin) alters nuclear morphology and gene expression. Current therapy increases the lifespan of these children only modestly.
View Article and Find Full Text PDFEthanol exposure during pregnancy is an established cause of birth defects, including neurodevelopmental defects. Most adult neurons are produced during the second trimester-equivalent period. The fetal neural stem cells (NSCs) that generate these neurons are an important but poorly understood target for teratogenesis.
View Article and Find Full Text PDFArticle Synopsis
- * The study utilized flow cytometry and qRT-PCR on mouse-derived neurosphere cultures, confirming the vulnerability of specific NSC populations to ethanol through both in vitro and in vivo assessments.
- * Results indicate that ethanol disrupts the ability of CD24(+) cells to differentiate properly and integrate into the fetal brain, suggesting that their loss could lead to impaired neurogenesis and development.