Publications by Rhonda C Kaufman

Publications by authors named "Rhonda C Kaufman"

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Ritonavir greatly impairs CYP3A activity in HIV infection with chronic viral hepatitis.

Tamsin A Knox Lauren Oleson Lisa L von Moltke Rhonda C Kaufman Christine A Wanke

J Acquir Immune Defic Syndr

December 2008

Purpose: Ritonavir is a powerful inhibitor of cytochrome P450 3A (CYP3A) that metabolizes many antiretrovirals. We examined the effect of ritonavir and of chronic viral hepatitis (CVH) status on CYP3A activity.

Methods: Twenty-six HIV-positive men (13 with CVH, 16 on chronic ritonavir-based highly active antiretroviral therapy) received oral and intravenous midazolam, a probe for CYP3A phenotypic activity.

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