Publications by authors named "Rhoda Owiti"
Background: Alternative treatments for visceral leishmaniasis (VL) are required in East Africa. Paromomycin sulphate (PM) has been shown to be efficacious for VL treatment in India.
Methods: A multi-centre randomized-controlled trial (RCT) to compare efficacy and safety of PM (20 mg/kg/day for 21 days) and PM plus sodium stibogluconate (SSG) combination (PM, 15 mg/kg/day and SSG, 20 mg/kg/day for 17 days) with SSG (20 mg/kg/day for 30 days) for treatment of VL in East Africa.
Article Synopsis
- Visceral leishmaniasis (VL) is a serious health concern in developing countries, with limited and costly treatment options, highlighting the urgent need for better therapies.
- A clinical trial compared paromomycin (PM) and sodium stibogluconate (SSG) as treatments for VL in East Africa, but PM had significantly lower cure rates (63.8%) compared to SSG (92.2%) and was less effective in Sudan specifically.
- The study concluded that the effectiveness of PM at its tested dosage was insufficient, particularly in Sudan, indicating that further research on higher doses and combination therapies is necessary.