Walking as a Mediator Between Strength and Health-Related Quality of Life in Multiple Sclerosis.

Unlabelled: Background and Purpose: Lower limb (LL) weakness and gait impairment are prevalent among persons with multiple sclerosis (PwMS) and can impede functional independence and impact health-related quality of life (HR-QoL). The purpose of this study was to examine the mediation effect of walking speed and perceived walking ability on the relationship between LL weakness and HR-QoL in ambulatory PwMS.

Methods: Participants (n = 175) were PwMS in this secondary analysis of a cross-sectional study.