Publications by authors named "Rhiannon Clements"
Article Synopsis
- The self-organization of cells is crucial for healthy tissue development, and cytonemes facilitate long-distance signaling between cells.
- Myosin XV, an unconventional myosin, plays a key role in regulating the dynamics of these cytonemes during sensory bristle patterning in fruit flies.
- Loss of Myosin XV results in longer and more numerous cytonemes that disrupt signaling between cells, indicating that Myosin XV negatively regulates their formation to ensure effective Notch signaling.
The self-organization of cells during development is essential for the formation of healthy tissues, and requires the coordination of cell activities at local scales. Cytonemes, or signaling filopodia, are dynamic actin-based cellular protrusions that allow cells to engage in contact mediated signaling at a distance. While signaling filopodia have been shown to support several signaling paradigms during development, less is understood about how these protrusions are regulated.
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