Publications by authors named "Rhian Raftopoulos"
Article Synopsis
- * In a study of 43 patients, most were confirmed or probable COVID-19 cases, revealing five main categories of neurological disorders: encephalopathies, inflammatory central nervous system syndromes, ischemic strokes, peripheral neurological disorders, and other central disorders.
- * Treatment outcomes varied, with many patients showing full or partial recovery, particularly those with encephalopathy and inflammatory CNS syndromes, while some experienced severe conditions like stroke or Guillain-Barré syndrome.
Background: Acute demyelinating optic neuritis, a common feature of multiple sclerosis, can damage vision through neurodegeneration in the optic nerve and in its fibres in the retina. Inhibition of voltage-gated sodium channels is neuroprotective in preclinical models. In this study we aimed to establish whether sodium-channel inhibition with phenytoin is neuroprotective in patient with acute optic neuritis.
View Article and Find Full Text PDFPurpose: To present a new acquisition and analysis protocol for reliable and reproducible segmentation of the entire intraorbital optic nerve (ION) mean cross-sectional area by means of magnetic resonance imaging (MRI) at 3 tesla (T).
Methods: Eight healthy volunteers (mean age 31, five were male) gave written informed consent and both of their IONs were imaged individually using a coronal-oblique T2-weighted fast multidynamic image acquisition scheme; the proposed acquisition scheme has its rationale in combining separately acquired volumes and registering them to account for motion-related artifacts commonly associated with longer acquisitions. Mean cross-sectional area of each ION was measured using a semiautomated image analysis protocol that was based on an active surface model previously described and used for spinal cord imaging.