Publications by authors named "Rhian L Preece"
Article Synopsis
- - Mood disorders impact millions globally and current diagnostic methods often lead to delays in accurate diagnosis, highlighting the need for improved approaches that can facilitate early identification of these conditions.
- - The Delta Trial aims to create an algorithm that combines symptom data with proteomic biomarkers to enhance diagnostic accuracy, particularly to differentiate between bipolar disorder and major depressive disorder.
- - Over 3200 people participated in the Delta Trial, with hundreds providing necessary blood samples and completing follow-up questionnaires, which supports the trial's potential in developing more effective diagnostic methods.
Major depressive disorder (MDD) and bipolar disorder (BD) are leading causes of disability worldwide, yet many people remain undiagnosed, are misdiagnosed, and/or ineffectively treated. Diagnosis relies on the clinical assessment of symptoms, and there is currently no molecular or brain-imaging diagnostic test available. Identifying and validating protein biomarkers could provide a more accurate and objective means of diagnosis.
View Article and Find Full Text PDFA rapid method to determine quality for placental proteomic studies is required due to varying lengths of time between delivery and sampling in routine protocols. We developed a rapid 10 min LC-MS based scanning method to profile free peptides liberated from natural proteolytic degradation. The assay was applied to placenta samples obtained following refrigeration for varying time periods post-delivery (12 h, +24 h, +48 h and +72 h).
View Article and Find Full Text PDF