Dissecting Heterogeneity in Functional Network Connectivity Aberrations in Antipsychotic Medication-Naïve First Episode Psychosis Patients - A Normative Modeling Study.

Importance: While there is a general consensus that functional connectome pathology is a key mechanism underlying psychosis spectrum disorders, the literature is plagued with inconsistencies and translation into clinical practice is non-existent. This is perhaps because group-level findings may not be accurate reflections of pathology at the individual patient level.

Objective: To characterize inter-individual heterogeneity in functional networks and investigate if normative values can be leveraged to identify biologically less heterogeneous subgroups of patients.