Publications by authors named "Rhea Sanghavi"
Background: Adolescents comprise one-sixth of the world's population, yet there is no clear understanding of the features that promote adolescent-friendly services (AFS). The lack of clarity and consistency around a definition presents a gap in health services.
Methods: The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines.
Article Synopsis
- Bacteria like Group B Streptococcus (GBS) can lead to serious issues during pregnancy, including preterm births and infections in newborns.
- GBS produces an enzyme called hyaluronidase that breaks down a component called hyaluronan in the host, which weakens the immune response and allows the bacteria to spread more easily.
- This study reveals that GBS's hyaluronidase (HylB) promotes immune suppression during pregnancy and involves specific immune receptors (TLR2, TLR4) and the cytokine IL-10, highlighting the need for better understanding to create effective treatment options.
Article Synopsis
- Hemolytic lipids, like granadaene from Group B Streptococcus (GBS), are harmful to immune cells and contribute to infections in both newborns and adults.
- Immunization with a synthetic safe version of granadaene (R-P4) has shown to enhance immune responses, leading to improved protection against GBS infections in mice.
- Key immune cells, particularly CD4+ T cells and iNKT cells, play a crucial role in this protection, suggesting that targeting lipid cytotoxins could be an effective strategy for developing new therapies.