Publications by authors named "Rezzan Sadioglu"
Introduction: We aimed to evaluate the relationship between the hand fine motor skills of peritoneal dialysis (PD) practitioners and PD-related peritonitis.
Methods: This multicenter prospective observational study was conducted with 120 incident PD patients. Patients were divided into two groups who had PD-related peritonitis within the first year as Group 1, and those who did not as Group 2.
Background: In this study, we evaluated 3-month clinical outcomes of kidney transplant recipients (KTR) recovering from COVID-19 and compared them with a control group.
Method: The primary endpoint was death in the third month. Secondary endpoints were ongoing respiratory symptoms, need for home oxygen therapy, rehospitalization for any reason, lower respiratory tract infection, urinary tract infection, biopsy-proven acute rejection, venous/arterial thromboembolic event, cytomegalovirus (CMV) infection/disease and BK viruria/viremia at 3 months.
Article Synopsis
- Vascular calcifications (VCs) are common in hemodialysis patients and linked to higher mortality rates; this study explored the connection between VCs and warfarin use in these patients.
- The study included 76 hemodialysis patients, comparing 32 who had been on warfarin for over a year to 44 controls, and assessed VCs using specific scoring methods.
- Results showed that warfarin users had significantly higher Kauppila scores (indicating more vascular calcification) compared to controls, suggesting an independent association between warfarin treatment and increased vascular calcifications in the aorta of hemodialysis patients.
Tacrolimus has been used in pregnant organ recipients for >20 years, and the relationship between fetal complications and the amount of tacrolimus crossing the placenta is still controversial. We report the case of a kidney transplant recipient who used tacrolimus and gave birth to an offspring that developed, shortly after birth, an acute kidney injury caused by tacrolimus exposure, which was detected by measuring tacrolimus levels in the umbilical vein, as well as in maternal blood. Even if whole-blood levels of tacrolimus are within the therapeutic range throughout pregnancy, the amount of tacrolimus could reach toxic levels.
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- Cell-free DNA can be a useful diagnostic and prognostic tool in both blood cancers and solid tumors, potentially aiding in patient management.
- A study involving 177 allogeneic hematopoietic stem cell transplant recipients found that pre-transplant cell-free DNA levels were lower in patients with certain genetic markers and conditions, indicating it may reflect disease characteristics and potential complications.
- Despite these correlations, overall survival rates did not significantly differ between high and low cell-free DNA groups, suggesting that while it may signal complications, it doesn’t directly predict survival outcomes.
Article Synopsis
- Phosphate binder pill (PBP) burden is an important issue for patients on dialysis, as it can impact their health and treatment efficacy.
- The study involved 255 dialysis patients to assess how factors like Helicobacter pylori (HP) infection, proton pump inhibitors (PPIs), and NaHCO capsules influence duodenal pH and PBP burden.
- Results showed that patients with HP had a significantly higher PBP burden, especially those not using PPIs or NaHCO, suggesting that HP may lower duodenal pH and increase PBP requirements.
Familial Mediterranean fever (FMF) is an important and preventable cause of chronic kidney disease due to secondary amyloidosis. Although colchicine is the first-line therapy in patients with FMF with 60% to 65% complete remission rates, 5% to 10% of patients are colchicine-resistant and 5% to 10% of them are intolerant to the therapy. Anti-interleukin-1 agents, such as anakinra and canakinumab, are safe and efficient therapeutic options in patients with colchicine resistance or intolerance.
View Article and Find Full Text PDFIntroduction: Amyloid A amyloidosis is most commonly caused by familial Mediterranean fever (FMF) in Turkey. Amyloidosis secondary to FMF is an important cause of end-stage renal failure, and kidney transplantation (KT) in these cases can be complicated, with long-term results oftentimes inferior compared with organ transplant in patients without FMF. The present study aims to show the long-term results of patients with secondary amyloidosis caused by FMF undergoing KT .
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