Memantine for Prophylactic Treatment of Migraine Without Aura: A Randomized Double-Blind Placebo-Controlled Study.

Background: Uncontrolled studies in human have suggested that memantine might be a suitable option for migraine prophylaxis.

Objective: To assess the efficacy and tolerability of memantine for migraine prophylaxis.

Methods: This was a 12-week randomized double-blind placebo-controlled parallel-group study.