Exploring the Production Effect in Memory Reveals a Balanced Bilingual Advantage.

There is evidence suggesting that bilingual individuals demonstrate an advantage over monolinguals in performing various tasks related to memory and executive functions. The characteristics of this bilingual advantage are not unanimously agreed upon in the literature, and some even doubt it exists. The heterogeneity of the bilingual population may explain this inconsistency.

"Women's work": Gender and the physician workforce.

Historically, the physician professional identity and the organizational structure of Western medicine have been defined by masculine norms such as authority and assertiveness. The past five decades have seen a rapid shift in the demographics of attendees as medical schools, with equal numbers of women and men matriculants for nearly twenty years. Gender as a social, cultural, and structural variable continues to influence the physician workforce.

Expanding the Legacy: The National Library of Medicine Michael E. DeBakey Lecture in the History of Medicine.

In our 2021 article published in this journal, we described the development, historical significance, and impact of the National Library of Medicine (NLM) Michael E. DeBakey fellowship in the History of Medicine. This article focuses on a key part of the fellowship, the NLM Michael E.

Selma and Lois DeBakey: Icons of Medical Preservation.

  In his 2016 article published in this journal, Dr. William Winters described Selma and Lois DeBakey as "icons of medical communication" who believed that "nothing hinders communication as much as words, when they are used badly or incorrectly." This article bookends Winters' description by explaining how Selma and Lois DeBakey were also "icons of medical preservation" who asked, "Shall we nourish the biomedical archives as a viable and indispensable source of information, or shall we bury their ashes and lose a century or more of consequential scientific history?" In addressing this question posed by Selma and Lois DeBakey and spotlighting their answers in their own engaging words, we highlight the relevance of their advocacy for the medical humanities and its influence to inform humanistic approaches to science and medicine.

Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat.

Challenging environmental conditions can drive the evolution of extreme physiological traits. The naked mole-rat has evolved to survive and thrive in a low oxygen, high carbon dioxide environment that would be deadly to humans and most other mammals. The naked mole-rat's lifestyle is unusual in that this species combines subterranean living and living in large, social groups of up to 300 + individuals.

Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice.

The mitochondrial enzyme SIRT3 is an NAD-dependent deacetylase important in cell metabolism, and a decline in its protein expression or activity has been linked with insulin resistance in obesity, ageing and type 2 diabetes. While studies in SIRT3 knockout mice have dramatically improved our understanding of the function of SIRT3, the impact of increasing SIRT3 levels remains under-examined. In this study we investigated the effects of liver-specific SIRT3 overexpression in mice on mitochondrial function and metabolic profile in both isolated hepatocytes and in vivo.

History with Heart-and Impact: The National Library of Medicine Michael E. DeBakey Fellowship in the History of Medicine.

The National Library of Medicine (NLM) Michael E. DeBakey Fellowship in the History of Medicine is a unique program in a unique institution: the world's largest biomedical library, which is part of the National Institutes of Health (NIH). The fellowship is rooted in strong connections between its namesake and the NLM and is an expression of Dr.

The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.

The naked mole-rat (Heterocephalus glaber) has fascinated zoologists for at least half a century. It has also generated considerable biomedical interest not only because of its extraordinary longevity, but also because of unusual protective features (e.g.

A Sweet Story of Metabolic Innovation in the Naked Mole-Rat.

The naked mole-rat's (Heterocephalus glaber) social and subterranean lifestyle imposes several evolutionary pressures which have shaped its physiology. One example is low oxygen availability in a crowded burrow system which the naked mole-rat has adapted to via several mechanisms. Here we describe a metabolic rewiring which enables the naked mole-rat to switch substrates in glycolysis from glucose to fructose thereby circumventing feedback inhibition at phosphofructokinase (PFK1) to allow unrestrained glycolytic flux and ATP supply under hypoxia.

African Naked Mole-Rats Demonstrate Extreme Tolerance to Hypoxia and Hypercapnia.

Naked mole-rats are extremely tolerant to low concentrations of oxygen (hypoxia) and high concentrations of carbon dioxide (hypercapnia), which is consistent with the environment that they inhabit. Naked mole-rats combine subterranean living with living in very densely populated colonies where oxygen becomes depleted and carbon dioxide accumulates. In the laboratory, naked mole-rats fully recover from 5 h exposure to 5% O and 5 h exposure to 80% CO, whereas both conditions are rapidly lethal to similarly sized laboratory mice.

The Somatosensory World of the African Naked Mole-Rat.

The naked mole-rat (Heterocephalus glaber) is famous for its longevity and unusual physiology. This eusocial species that lives in highly ordered and hierarchical colonies with a single breeding queen, also discovered secrets enabling somewhat pain-free living around 20 million years ago. Unlike most mammals, naked mole-rats do not feel the burn of chili pepper's active ingredient, capsaicin, nor the sting of acid.

Measurement of Cognition for the National Children's Study.

The National Children's Study Cognitive Health Domain Team developed detailed plans for assessing cognition longitudinally from infancy to early adulthood. These plans identify high-priority aspects of cognition that can be measured efficiently and effectively, and we believe they can serve as a model for future large-scale longitudinal research. For infancy and toddlerhood, we proposed several paradigms that collectively allowed us to assess six broad cognitive constructs: (1) executive function skills, (2) episodic memory, (3) language, (4) processing speed, (5) spatial and numerical processing, and (6) social cognition.

Infant Attentional behaviors Are Associated With ADHD Symptomatology and Executive Function in Early Childhood.

We explored associations between infant attentional behaviors as measured by the First Year Inventory (FYIv2.0) and dimensional ratings of ADHD symptomatology and executive function (EF) in early childhood. This study included parents ( = 229) who filled out the FYIv2.

From postcard to book cover: illustrating connections between medical history and digital humanities.

This article illustrates the value and impact of collaboration among scholars, archivists, and librarians working across universities and government institutions, and how changes in medium-from a born-physical photograph and printed postcard to a digital reproduction to a simultaneously born-digital and printed book-create new possibilities for scholarly analysis, interpretation, and dissemination, which in turn suggest future directions for research and engagement across fields of inquiry. In doing so, this article argues that history matters by illuminating past networks that, through humanistic inquiry, continue to connect people, ideas, and institutions in the present and into the future.

The Performance of the First Year Inventory (FYI) Screening on a Sample of High-Risk 12-Month-Olds Diagnosed with Autism Spectrum Disorder (ASD) at 36 Months.

This study examined the performance of the First Year Inventory (FYI; version 2.0), a community-normed parent-reported screening instrument, in a high-risk (HR) sample of 12-month-olds with older siblings diagnosed with autism spectrum disorder (ASD). The FYI 2.

Rapid molecular evolution of pain insensitivity in multiple African rodents.

Noxious substances, called algogens, cause pain and are used as defensive weapons by plants and stinging insects. We identified four previously unknown instances of algogen-insensitivity by screening eight African rodent species related to the naked mole-rat with the painful substances capsaicin, acid (hydrogen chloride, pH 3.5), and allyl isothiocyanate (AITC).

Publisher Correction: Lipidome determinants of maximal lifespan in mammals.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Reduced insulin action in muscle of high fat diet rats over the diurnal cycle is not associated with defective insulin signaling.

Objective: Energy metabolism and insulin action follow a diurnal rhythm. It is therefore important that investigations into dysregulation of these pathways are relevant to the physiology of this diurnal rhythm.

Methods: We examined glucose uptake, markers of insulin action, and the phosphorylation of insulin signaling intermediates in muscle of chow and high fat, high sucrose (HFHS) diet-fed rats over the normal diurnal cycle.

Infant quantitative risk for autism spectrum disorder predicts executive function in early childhood.

Much of the current research concerning autism spectrum disorder (ASD) focuses on early identification of behaviors that may indicate future deficits or higher risk for a later diagnosis. Additionally, there exists a strong claim regarding the dimensional nature of ASD, such that even among non-diagnosed individuals, a continuous distribution of symptom severity can be observed. Executive function (EF) has been widely studied in children, adolescents, and adults with ASD, with a robust body of research supporting widespread EF deficits in diagnosed individuals.

The Predictive Value of Developmental Assessments at 1 and 2 for Intelligence Quotients at 6.

Intelligence is an important individual difference factor related to mental health, academic achievement, and life success, yet there is a lack of research into its early cognitive predictors. This study investigated the predictive value of infant developmental assessment scores for school-age intelligence in a large, heterogeneous sample of single- and twin-born subjects (N = 521). We found that Early Learning Composite (ELC) scores from the Mullen Scales of Early Learning have similar predictive power to that of other infant tests.

"A Noble Experiment in Human Values": The Children's Television Series and Its Initiative to Change the Environment for Racism in 1970s America.

This article explores the creation, production, and reception of the unique, popular, and publicly-funded mid-1970s children's television series Vegetable Soup, arguing that it constitutes a specific and intriguing chapter in the history of efforts in the United States to change "the environment for racism."