MicroRNA-331-3p inhibits proliferation and metastasis of ovarian cancer by targeting RCC2.

Introduction: Epithelial ovarian carcinoma (EOC) is one of the most lethal gynecologic malignancies, with a poor 5-year survival rate. Numerous studies have shown that microRNAs participate in the malignant behavior of ovarian cancer cells by directly targeting multiple oncogenes or tumor suppressor genes.

Material And Methods: Reverse transcription-PCR was used to determine the level of miR-331-3p in EOC.

Up-regulation of lncRNA FALEC indicates prognosis and diagnosis values in cervical cancer.

We examined the expression level of focally amplified lncRNA on chromosome 1 (FALEC) in cervical cancer patients and explore its clinical value in diagnosis and prognosis of cervical cancer. FALEC was significantly up-regulated in the blood plasma from cervical cancer patients and had significant correlation with tumor size, the FIGO stage, and lymph node metastasis. Furthermore, FALEC overexpression could stimulate proliferation and invasion of Hela cells.