Systematic development of self-emulsifying drug delivery systems of atorvastatin with improved bioavailability potential.

The aim of this study was to prepare and characterize a self-emulsifying drug delivery system (SEDDS) with a high drug load of poorly water-soluble atorvastatin for the enhancement of dissolution and oral bioavailability. Solubility of atorvastatin in oil, surfactant, and cosurfactant was determined. Pseudo-ternary phase diagrams were constructed by the aqueous titration method, and formulations were developed based on the optimum excipient combinations.

In vitro study on tamsulosin release kinetics from biodegradable PLGA in situ implants.

The objective of this study was to evaluate the effect of drug loading and the effect of excipients on the release pattern of tamsulosin tydrochloride from in situ PLGA implants formed in vitro in gelatin gel. This system is prepared by dissolving a biodegradable polymer (DL-PLGA 70K) in biocompatible solvent, dimethyl sulfoxide (DMSO). Then either the drug or drug with excipients was added to it.

Stability study of ambroxol hydrochloride sustained release pellets coated with acrylic polymer.

The aim of the present study is to perform stability study of ambroxol hydrochloride sustained release pellets stored in different storage conditions. The drug loaded beads were prepared by extrusion-spheronization technology then coated with ammonio methacrylate copolymer type A (Eudragit RL 30 D) and ammonio methacrylate copolymer type B (Eudragit RS 30 D) at a ratio of 2:3 (8% polymer by weight on dry basis) in fluid bed coater (Wurster column). Stability study of pellets was performed as capsule dosage form in aluminium-PVDC packaging mode at room temperature, 40 degrees C, 40 degrees C/75%RH & 30 degrees C/70%RH for three months.

Effect of plasticizer on release kinetics of diclofenac sodium pellets coated with Eudragit RS 30 D.

The present study was designed to investigate the effect of two plasticizers, i.e., triethyl citrate (TEC) and polyethylene glycol 6000 (PEG 6000) on the in vitro release kinetics of diclofenac sodium from sustained-release pellets.

The effect of the ratio of two acrylic polymers on the in vitro release kinetics of ketoprofen from pellets prepared by extrusion and spheronisation technique.

The aim of this study was to investigate the effect of physico-chemical properties of the polymers on the release profile of ketoprofen from the pellets dosage form. Ammonio Methacrylate Copolymer Type A (Eudragit RL 30 D) & Ammonio Methacrylate Copolymer Type B (Eudragit RS 30 D) were used as release rate retarding polymers. The drug containing core pellets were prepared by extrusion spheronisation technique and subsequently coated with 15% (w/w) polymer load of the combination of Eudragit RL 30 D & Eudragit RS 30 D having ratio 1:0, 4:1, 3:2, 1:1, 2:3, 1:4, 0:1 respectively.