Publications by authors named "Reza Torshizi"
Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division.
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- * In a study of 43 HTLV-1-infected individuals, ATLL patients had significantly higher expression levels of these oncogenes and higher proviral load (PVL) compared to asymptomatic carriers.
- * A negative correlation was found between PVL and survival rates in ATLL patients, suggesting that tracking these viral markers could help predict patient outcomes and inform treatment strategies.