Numerical and Experimental Analysis of Drug Inhalation in Realistic Human Upper Airway Model.

The demand for a more efficient and targeted method for intranasal drug delivery has led to sophisticated device design, delivery methods, and aerosol properties. Due to the complex nasal geometry and measurement limitations, numerical modeling is an appropriate approach to simulate the airflow, aerosol dispersion, and deposition for the initial assessment of novel methodologies for better drug delivery. In this study, a CT-based, 3D-printed model of a realistic nasal airway was reconstructed, and airflow pressure, velocity, turbulent kinetic energy (TKE), and aerosol deposition patterns were simultaneously investigated.

Investigation of airflow at different activity conditions in a realistic model of human upper respiratory tract.

In the present study, the turbulent flows inside a realistic model of the upper respiratory tract were investigated numerically and experimentally. The airway model included the geometrical details of the oral cavity to the end of the trachea that was based on a series of CT-scan images. The topological data of the respiratory tract were used for generating the computational model as well as the 3D-printed model that was used in the experimental pressure drop measurement.

Laminar-to-turbulence and relaminarization zones detection by simulation of low Reynolds number turbulent blood flow in large stenosed arteries.

Laminar, turbulent, transitional, or combine areas of all three types of viscous flow can occur downstream of a stenosis depending upon the Reynolds number and constriction shape parameter. Neither laminar flow solver nor turbulent models for instance the k-ω (k-omega), k-ε (k-epsilon), RANS or LES are opportune for this type of flow. In the present study attention has been focused vigorously on the effect of the constriction in the flow field with a unique way.