Publications by authors named "Reza Salahlou"

Article Synopsis
  • * Mesenchymal stem cells (MSCs), which can be sourced from tissues like bone marrow and adipose, have unique properties that make them promising for cancer treatment, including their ability to differentiate into various cell types and target tumors.
  • * MSCs and their exosomes show potential in delivering therapeutic agents and inhibiting cancer progression by disrupting key signaling pathways, but challenges remain in effectively utilizing them in therapies.
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Background: Human polyomaviruses contribute to human oncogenesis through persistent infections, but currently there is no effective preventive measure against the malignancies caused by this virus. Therefore, the development of a safe and effective vaccine against HPyV is of high priority.

Methods: First, the proteomes of 2 polyomavirus species (HPyV6 and HPyV7) were downloaded from the NCBI database for the selection of the target proteins.

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Exploration of tumor immunity leads to the development of immune checkpoint inhibitors and cell-based immunotherapies which improve the clinical outcomes in several tumor types. However, the poor clinical efficacy of these treatments observed for other tumors could be attributed to the inherent complex tumor microenvironment (TME), cellular heterogeneity, and stemness driven by cancer stem cells (CSCs). CSC-specific characteristics provide the bulk tumor surveillance and resistance to entire eradication upon conventional therapies.

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Understanding the molecular mechanisms of cancer biology introduces targeted therapy as a complementary method along with other conventional therapies. Recombinant immunotoxins are tumor specific antibodies that their recognizing fragment is utilized for delivering modified toxins into tumor cells. These molecules have been considered as a targeted strategy in the treatment of human cancers.

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